{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,19]],"date-time":"2025-12-19T15:10:23Z","timestamp":1766157023699,"version":"build-2065373602"},"reference-count":22,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2005,3,4]],"date-time":"2005-03-04T00:00:00Z","timestamp":1109894400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Movement Disorders"],"published-print":{"date-parts":[[2005,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>We conducted an open\u2010label, dose\u2010finding, blinded\u2010rating trial of \u03b3\u2010hydroxybutyric acid (Xyrem) in a single patient with severe alcohol\u2010responsive posthypoxic myoclonus refractory to treatment with standard antimyoclonic agents. Xyrem was given in divided doses during the day and was well tolerated. Intensity of myoclonus was measured using the Unified Myoclonus Rating Scale, and blinded videotape review demonstrated complete resolution of myoclonus at rest and stimulus\u2010sensitive myoclonus. Action myoclonus and functional performance also improved in ways that were practically meaningful, allowing her to feed herself, to accomplish daily hygiene tasks, and to walk with assistance. The possible mechanisms of action and potential uses of this agent in other alcohol\u2010responsive movement disorders are discussed. \u00a9 2005 Movement Disorder Society<\/jats:p>","DOI":"10.1002\/mds.20452","type":"journal-article","created":{"date-parts":[[2005,3,4]],"date-time":"2005-03-04T13:16:34Z","timestamp":1109942194000},"page":"745-751","source":"Crossref","is-referenced-by-count":18,"title":["Marked amelioration of alcohol\u2010responsive posthypoxic myoclonus by \u03b3\u2010hydroxybutyric acid (Xyrem)"],"prefix":"10.1002","volume":"20","author":[{"given":"Steven J.","family":"Frucht","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yvette","family":"Bordelon","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"William H.","family":"Houghton","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,3,4]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/86.1.111"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1002\/mds.870150702"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1212\/01.WNL.0000125336.05001.23"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.wco.0000084231.82329.9c"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1002\/mds.870110629"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1002\/mds.870070122"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1002\/mds.870060219"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.40.9.1412"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.54.8.1706"},{"key":"e_1_2_6_11_2","series-title":"Myoclonus and paroxysmal dyskinesias. Advances in neurology","first-page":"361","author":"Frucht SJ","year":"2002"},{"key":"e_1_2_6_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.tips.2003.11.001"},{"key":"e_1_2_6_13_2","first-page":"43","article-title":"Gamma\u2010hydroxybutryic acid 9GHB) and its chemical modifications: a review of the GHBergic system","volume":"56","author":"Waszkielewicz A","year":"2004","journal-title":"Pol J Pharmacol"},{"key":"e_1_2_6_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0741-8329(99)00093-2"},{"key":"e_1_2_6_15_2","first-page":"83","article-title":"Gamma\u2010hydroxybutyric acid in the treatment of alcohol withdrawal syndrome in patients admitted to hospital","volume":"30","author":"Korninger C","year":"2003","journal-title":"Acta Med Austriaca"},{"key":"e_1_2_6_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0376-8716(98)00094-5"},{"key":"e_1_2_6_17_2","doi-asserted-by":"publisher","DOI":"10.2165\/00002018-200427050-00002"},{"key":"e_1_2_6_18_2","first-page":"42","article-title":"A randomized, double\u2010blind, placebo\u2010controlled multicenter trial comparing the effects of three doses of orally administered sodium oxybate with placebo for the treatment of narcolepsy","volume":"25","author":"US Xyrem Multicenter Study Group","year":"2002","journal-title":"Sleep"},{"key":"e_1_2_6_19_2","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/117.3.477"},{"key":"e_1_2_6_20_2","doi-asserted-by":"publisher","DOI":"10.1002\/mds.1119"},{"key":"e_1_2_6_21_2","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.67.3.415"},{"key":"e_1_2_6_22_2","doi-asserted-by":"publisher","DOI":"10.1097\/00002826-199204000-00001"},{"key":"e_1_2_6_23_2","doi-asserted-by":"publisher","DOI":"10.1212\/01.WNL.0000101722.95137.19"}],"container-title":["Movement Disorders"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fmds.20452","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/movementdisorders.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/mds.20452","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T13:01:33Z","timestamp":1760965293000},"score":1,"resource":{"primary":{"URL":"https:\/\/movementdisorders.onlinelibrary.wiley.com\/doi\/10.1002\/mds.20452"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005,3,4]]},"references-count":22,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2005,6]]}},"alternative-id":["10.1002\/mds.20452"],"URL":"https:\/\/doi.org\/10.1002\/mds.20452","archive":["Portico"],"relation":{},"ISSN":["0885-3185","1531-8257"],"issn-type":[{"type":"print","value":"0885-3185"},{"type":"electronic","value":"1531-8257"}],"subject":[],"published":{"date-parts":[[2005,3,4]]}}}