{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T17:47:21Z","timestamp":1775065641440,"version":"3.50.1"},"reference-count":22,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2005,4,25]],"date-time":"2005-04-25T00:00:00Z","timestamp":1114387200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Movement Disorders"],"published-print":{"date-parts":[[2005,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>We electrophysiologically examined the transition from physiologic tremor to essential tremor in people at risk for familial essential tremor. Two healthy people from different families with hereditary essential tremor were studied on multiple occasions. A 23\u2010year\u2010old man was studied in 1995, 1997, and 2004, and a 44\u2010year\u2010old woman was studied in 1993, 1995, 1997, and 2003. Hand acceleration and forearm electromyographic readings were measured with and without 300\u2010g loading to determine the characteristic frequency\u2010invariant motor unit entrainment of essential tremor. Clinically and electrophysiologically, the man and woman had normal tremor until the last examination, when both exhibited a fine tremulousness in the outstretched hands and frequency\u2010invariant motor unit entrainment at 7.5 and 6.5 Hz, respectively. At no time did either patient exhibit a prominent 8\u201312 Hz component of physiologic tremor. Essential tremor in young adults may begin at frequencies less than 8\u201312 Hz, and this electrophysiologic abnormality is detectable when clinical examinations reveal only questionably abnormal tremor. More young adults at risk for essential tremor must be studied to determine whether initial frequencies less than 8 Hz are the rule or the exception. Nevertheless, the data from our 2 patients demonstrate that a prominent 8\u201312 Hz component of physiologic tremor does not always precede the development of essential tremor; therefore, the origins of essential tremor and the 8\u201312 Hz component of physiologic tremor may be different. \u00a9 2005 Movement Disorder Society<\/jats:p>","DOI":"10.1002\/mds.20487","type":"journal-article","created":{"date-parts":[[2005,4,25]],"date-time":"2005-04-25T12:50:49Z","timestamp":1114433449000},"page":"1038-1042","source":"Crossref","is-referenced-by-count":33,"title":["Electrophysiologic transition from physiologic tremor to essential tremor"],"prefix":"10.1002","volume":"20","author":[{"given":"Rodger J.","family":"Elble","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Connie","family":"Higgins","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Suzanne","family":"Elble","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,4,25]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1567-4231(09)70170-4"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/92.3.647"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/0013-4694(78)90106-2"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/102.3.509"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.43.3.248"},{"key":"e_1_2_6_7_2","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1152\/jn.1980.44.1.40","article-title":"Mechanical and neural feedback factors in postural hand tremor of normal subjects","volume":"44","author":"Stiles RN","year":"1980","journal-title":"J Neurophysiol"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1388-2457(03)00006-3"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.1996.sp021432"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-7793.1999.00929.x"},{"key":"e_1_2_6_11_2","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1152\/jappl.1970.29.1.103","article-title":"Relationship between forearm tremor and the biceps electromyogram","volume":"29","author":"Fox JR","year":"1970","journal-title":"J Appl Physiol"},{"key":"e_1_2_6_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/0013-4694(74)90202-8"},{"key":"e_1_2_6_13_2","doi-asserted-by":"publisher","DOI":"10.1152\/jn.1976.39.2.370"},{"key":"e_1_2_6_14_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00221-001-0914-7"},{"key":"e_1_2_6_15_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.54.4.14A"},{"key":"e_1_2_6_16_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.36.2.225"},{"key":"e_1_2_6_17_2","doi-asserted-by":"publisher","DOI":"10.1002\/mds.870090602"},{"key":"e_1_2_6_18_2","first-page":"225","volume-title":"Parkinson's disease and movement disorders","author":"Fahn S","year":"1993"},{"key":"e_1_2_6_19_2","first-page":"1759","volume-title":"Neuromuscular function and disease: basic, clinical and electrodiagnostic aspects","author":"Elble RJ","year":"2002"},{"key":"e_1_2_6_20_2","doi-asserted-by":"publisher","DOI":"10.1002\/mds.870110113"},{"issue":"3","key":"e_1_2_6_21_2","first-page":"2","article-title":"Consensus statement of the Movement Disorder Society on Tremor","volume":"13","author":"Deuschl G","year":"1998","journal-title":"Mov Disord"},{"key":"e_1_2_6_22_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1388-2457(00)00384-9"},{"key":"e_1_2_6_23_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.55.10.1547"}],"container-title":["Movement Disorders"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fmds.20487","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/movementdisorders.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/mds.20487","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T10:19:34Z","timestamp":1760955574000},"score":1,"resource":{"primary":{"URL":"https:\/\/movementdisorders.onlinelibrary.wiley.com\/doi\/10.1002\/mds.20487"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005,4,25]]},"references-count":22,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2005,8]]}},"alternative-id":["10.1002\/mds.20487"],"URL":"https:\/\/doi.org\/10.1002\/mds.20487","archive":["Portico"],"relation":{},"ISSN":["0885-3185","1531-8257"],"issn-type":[{"value":"0885-3185","type":"print"},{"value":"1531-8257","type":"electronic"}],"subject":[],"published":{"date-parts":[[2005,4,25]]}}}