{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T10:59:22Z","timestamp":1791543562679,"version":"4.3.4"},"reference-count":14,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2005,4,27]],"date-time":"2005-04-27T00:00:00Z","timestamp":1114560000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Movement Disorders"],"published-print":{"date-parts":[[2005,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>In Parkinson's disease, dopamine dysregulation syndrome (DDS) is characterized by severe dopamine addiction and behavioral disorders such as manic psychosis, hypersexuality, pathological gambling, and mood swings. Here, we describe the case of 2 young parkinsonian patients suffering from disabling motor fluctuations and dyskinesia associated with severe DDS. In addition to alleviating the motor disability in both patients, subthalamic nucleus (STN) deep brain stimulation greatly reduced the behavioral disorders as well as completely abolished the addiction to dopaminergic treatment. Dopaminergic addiction in patients with Parkinson's disease, therefore, does not constitute an obstacle to high\u2010frequency STN stimulation, and this treatment may even cure the addiction. \u00a9 2005 Movement Disorder Society<\/jats:p>","DOI":"10.1002\/mds.20501","type":"journal-article","created":{"date-parts":[[2005,4,27]],"date-time":"2005-04-27T18:16:56Z","timestamp":1114625816000},"page":"1052-1055","source":"Crossref","is-referenced-by-count":209,"title":["Addiction in Parkinson's disease: Impact of subthalamic nucleus deep brain stimulation"],"prefix":"10.1002","volume":"20","author":[{"given":"Tatiana","family":"Witjas","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christelle","family":"Baunez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean Marc","family":"Henry","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marie","family":"Delfini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean","family":"Regis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andr\u00e9 Ali","family":"Cherif","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean Claude","family":"Peragut","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean Philippe","family":"Azulay","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2005,4,27]]},"reference":[{"key":"e_1_2_5_2_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.278.5335.52"},{"key":"e_1_2_5_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(03)00529-5"},{"key":"e_1_2_5_4_2","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.68.4.423"},{"key":"e_1_2_5_5_2","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.72.6.701"},{"key":"e_1_2_5_6_2","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/123.10.2091"},{"key":"e_1_2_5_7_2","doi-asserted-by":"publisher","DOI":"10.1212\/01.WNL.0000032756.14298.18"},{"key":"e_1_2_5_8_2","first-page":"724.4","article-title":"Opposite effects of subthalamic nucleus lesions on motivation for natural reward versus drugs of abuse in rats","volume":"29","author":"Baunez C","year":"2003","journal-title":"Soci Neurosci Abstr"},{"key":"e_1_2_5_9_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1471-4159.2003.01646.x"},{"key":"e_1_2_5_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0165-0173(99)00023-5"},{"key":"e_1_2_5_11_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.psych.54.101601.145237"},{"key":"e_1_2_5_12_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa035275"},{"key":"e_1_2_5_13_2","doi-asserted-by":"publisher","DOI":"10.1002\/mds.10518"},{"key":"e_1_2_5_14_2","doi-asserted-by":"publisher","DOI":"10.1002\/mds.10441"},{"key":"e_1_2_5_15_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa000827"}],"container-title":["Movement Disorders"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fmds.20501","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/movementdisorders.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/mds.20501","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T10:19:35Z","timestamp":1760955575000},"score":1,"resource":{"primary":{"URL":"https:\/\/movementdisorders.onlinelibrary.wiley.com\/doi\/10.1002\/mds.20501"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005,4,27]]},"references-count":14,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2005,8]]}},"alternative-id":["10.1002\/mds.20501"],"URL":"https:\/\/doi.org\/10.1002\/mds.20501","archive":["Portico"],"relation":{},"ISSN":["0885-3185","1531-8257"],"issn-type":[{"value":"0885-3185","type":"print"},{"value":"1531-8257","type":"electronic"}],"subject":[],"published":{"date-parts":[[2005,4,27]]}}}