{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,4]],"date-time":"2026-06-04T13:40:11Z","timestamp":1780580411866,"version":"3.54.1"},"reference-count":35,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2005,6,13]],"date-time":"2005-06-13T00:00:00Z","timestamp":1118620800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Movement Disorders"],"published-print":{"date-parts":[[2005,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>We investigated the effects of high\u2010external\u2010temperature exposure on neurogenic orthostatic hypotension (OH). Thirty\u2010one patients with autonomic failure (AF) and pharmacologically treated OH related to probable multiple\u2010system atrophy (n = 7), Parkinson's disease (n = 10), pure autonomic failure (n = 7), and diffuse Lewy body disease (n = 7) and 26 parkinsonians without AF were included. Prevalence and severity of clinical events were studied during the August 2003 heat wave and the 2004 summer. The prevalence of OH\u2010related events was significantly higher in 2003 [45.1 vs. 11.5%; <jats:italic>P<\/jats:italic> = 0.0052; OR = 6.31 (1.35\u201333.53)] and 2004 [42.3 vs. 12.0%; <jats:italic>P<\/jats:italic> = 0.014; OR = 5.40 (1.28\u201322.68)] in AF than in controls. The mean severity score for clinical events was significantly higher in AF than in controls during 2003 heat wave (1.2 \u00b1 1.4 vs. 0.2 \u00b1 0.5) but similar in summer 2004 (0.7 \u00b1 1.0 vs. 0.1 \u00b1 0.3). Severe events (unusual home care, assistance, or hospitalization) were only observed in AF patients. A nonstatistically significant higher prevalence of clinical events was observed in AF patients prescribed fludrocortisone (66.7%) by comparison to heptaminol (42.9%), midodrine (45.5%), or midodrine plus fludrocortisone (28.6%). This study shows that AF patients have a poor clinical outcome when exposed to high temperatures and that heat exposure is a risk factor for OH worsening. \u00a9 2005 Movement Disorder Society<\/jats:p>","DOI":"10.1002\/mds.20571","type":"journal-article","created":{"date-parts":[[2005,6,13]],"date-time":"2005-06-13T18:46:34Z","timestamp":1118688394000},"page":"1213-1219","source":"Crossref","is-referenced-by-count":29,"title":["Heat\u2010related morbidity in patients with orthostatic hypotension and primary autonomic failure"],"prefix":"10.1002","volume":"20","author":[{"given":"Atul","family":"Pathak","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maryse","family":"Lapeyre\u2010Mestre","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean\u2010Louis","family":"Montastruc","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean\u2010Michel","family":"Senard","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2005,6,13]]},"reference":[{"key":"e_1_2_5_2_2","first-page":"17","volume-title":"Autonomic failure: a textbook of clinical disorders of the autonomic nervous system","author":"Bannister R","year":"1999"},{"key":"e_1_2_5_3_2","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.63.5.584"},{"key":"e_1_2_5_4_2","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.67.5.620"},{"key":"e_1_2_5_5_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.38.10.1520"},{"key":"e_1_2_5_6_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.31.10.2307"},{"key":"e_1_2_5_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0895-7061(99)00257-5"},{"key":"e_1_2_5_8_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.98.21.2290"},{"key":"e_1_2_5_9_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.HYP.18.5.694"},{"key":"e_1_2_5_10_2","doi-asserted-by":"publisher","DOI":"10.2165\/00002018-199717020-00003"},{"key":"e_1_2_5_11_2","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1968.25.3.268"},{"key":"e_1_2_5_12_2","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1970.28.4.428"},{"key":"e_1_2_5_13_2","first-page":"1343","article-title":"Orthostatic responses in caucasians and Bantu","volume":"46","author":"Shvartz E","year":"1975","journal-title":"Aviat Space Environ Med"},{"key":"e_1_2_5_14_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00420-001-0290-4"},{"key":"e_1_2_5_15_2","doi-asserted-by":"crossref","first-page":"799","DOI":"10.1097\/00007611-200295080-00006","article-title":"Drug\u2010associated heat stroke","volume":"95","author":"Martinez M","year":"2002","journal-title":"South Med J"},{"key":"e_1_2_5_16_2","first-page":"105","article-title":"High summer temperatures and mortality in the Czech Republic 1988\u20132000","volume":"52","author":"Kysely J","year":"2003","journal-title":"Epidemiol Mikrobiol Immunol"},{"key":"e_1_2_5_17_2","first-page":"41","article-title":"Wisconsin, July 1999 heat wave: an epidemiological assessment","volume":"99","author":"Rajpal RC","year":"2000","journal-title":"Wis Med J"},{"key":"e_1_2_5_18_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199607113350203"},{"key":"e_1_2_5_19_2","doi-asserted-by":"publisher","DOI":"10.1136\/jech.57.8.628"},{"key":"e_1_2_5_20_2","doi-asserted-by":"publisher","DOI":"10.1007\/s004840050127"},{"key":"e_1_2_5_21_2","doi-asserted-by":"publisher","DOI":"10.1093\/aje\/kwg096"},{"key":"e_1_2_5_22_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM200311203492120"},{"key":"e_1_2_5_23_2","unstructured":"HemonD JoulaE. 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