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We extend this preliminary observation to five other patients with ethanol\u2010responsive movement disorders in an open\u2010label, dose\u2010titration, add\u2010on, 8\u2010week trial. All five patients (one with severe alcohol\u2010responsive posthypoxic myoclonus, two with \u03f5\u2010sarcoglycan\u2013linked myoclonus\u2013dystonia, and two with essential tremor) experienced improvement from baseline of 50% or greater as measured by blinded videotape review. Tolerability was satisfactory, with dose\u2010dependent sedation as the most common side effect. Further studies of this drug in hyperkinetic movement disorders are warranted. \u00a9 2005 Movement Disorder Society<\/jats:p>","DOI":"10.1002\/mds.20605","type":"journal-article","created":{"date-parts":[[2005,6,28]],"date-time":"2005-06-28T17:18:30Z","timestamp":1119979110000},"page":"1330-1337","source":"Crossref","is-referenced-by-count":73,"title":["A pilot tolerability and efficacy trial of sodium oxybate in ethanol\u2010responsive movement disorders"],"prefix":"10.1002","volume":"20","author":[{"given":"Steven J.","family":"Frucht","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yvette","family":"Bordelon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William 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