{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,20]],"date-time":"2026-05-20T05:43:30Z","timestamp":1779255810826,"version":"3.51.4"},"reference-count":15,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2005,8,9]],"date-time":"2005-08-09T00:00:00Z","timestamp":1123545600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Korea Health 21 R&D Project"},{"name":"Ministry of Health and Welfare, Republic of Korea","award":["03-PJ1-PG1-CH07-0004"],"award-info":[{"award-number":["03-PJ1-PG1-CH07-0004"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Movement Disorders"],"published-print":{"date-parts":[[2005,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Essential tremor (ET) is the most common but a complex neurological movement disorder. ET usually affects hands, but it may also affect head, neck, face, jaw, tongue, voice, trunk and, rarely, legs and feet. Although two susceptibility loci were identified on chromosome 2p24 (<jats:italic>ETM2<\/jats:italic>) and 3q13 (<jats:italic>ETM1<\/jats:italic> or <jats:italic>FET1<\/jats:italic>), the exact transcript(s) has not been cloned. We analyzed unrelated Korean individuals with ET for a genetic association with three reported polymorphic loci (<jats:italic>STS\u2010etm1240, STS\u2010etm1231<\/jats:italic>, and <jats:italic>STS\u2010etm1234<\/jats:italic>) in a candidate region on chromosome 2p24.1. We investigated sequence polymorphisms at these three loci in 30 ET patients and 30 controls using polymerase chain reaction (PCR) amplification followed by sequence analysis. Eight different sequence variants (5 at <jats:italic>etm1234<\/jats:italic>, 2 at <jats:italic>etm1240<\/jats:italic>, and 1 at <jats:italic>etm1231<\/jats:italic>) were detected from 7 patients. Of interest, sequence variants were found only in classic ET patients but not in nonclassic ET patients and healthy individuals. Additionally, we also observed that a decrease in the number of short tandem repeats within <jats:italic>etm1234<\/jats:italic> locus is more frequent in ET patients compared to controls. Our data thus support that ET development would be linked with the <jats:italic>ETM2<\/jats:italic> locus and will facilitate the search for the <jats:italic>ETM2<\/jats:italic> gene transcript. \u00a9 2005 Movement Disorder Society<\/jats:p>","DOI":"10.1002\/mds.20646","type":"journal-article","created":{"date-parts":[[2005,8,9]],"date-time":"2005-08-09T13:47:05Z","timestamp":1123595225000},"page":"1650-1653","source":"Crossref","is-referenced-by-count":11,"title":["Frequent sequence variation at the <i>ETM2<\/i> locus and its association with sporadic essential tremor in Korea"],"prefix":"10.1002","volume":"20","author":[{"given":"Jeong\u2010Hyun","family":"Kim","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoon\u2010Hee","family":"Cho","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jeong\u2010Kook","family":"Kim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yong\u2010Gou","family":"Park","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jin Woo","family":"Chang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,8,9]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1002\/mds.870131310"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1002\/mds.870120620"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1002\/mds.870120605"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1002\/mds.870130621"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1038\/ng0997-84"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10048-003-0151-2"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-0004.2004.00306.x"},{"key":"e_1_2_6_9_2","first-page":"S2","article-title":"Diagnostic criteria for essential tremor and differential diagnosis","volume":"54","author":"Elble RJ","year":"2000","journal-title":"Neurology"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/bth457"},{"key":"e_1_2_6_11_2","doi-asserted-by":"publisher","DOI":"10.1101\/gr.10.7.967"},{"key":"e_1_2_6_12_2","first-page":"780","article-title":"From gene to disease; from DNA 'mismatch' repair genes to hereditary non\u2010polyposis colorectal carcinoma","volume":"145","author":"Wijnen JT","year":"2001","journal-title":"Ned Tijdschr Geneeskd"},{"key":"e_1_2_6_13_2","doi-asserted-by":"publisher","DOI":"10.1097\/00125817-200105000-00009"},{"key":"e_1_2_6_14_2","doi-asserted-by":"publisher","DOI":"10.1002\/1531-8257(200009)15:5<1020::AID-MDS1044>3.0.CO;2-G"},{"key":"e_1_2_6_15_2","doi-asserted-by":"publisher","DOI":"10.1007\/s100720170036"},{"key":"e_1_2_6_16_2","doi-asserted-by":"publisher","DOI":"10.1038\/ng1456"}],"container-title":["Movement Disorders"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fmds.20646","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fmds.20646","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/mds.20646","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/mds.20646","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/movementdisorders.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/mds.20646","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T11:17:53Z","timestamp":1760959073000},"score":1,"resource":{"primary":{"URL":"https:\/\/movementdisorders.onlinelibrary.wiley.com\/doi\/10.1002\/mds.20646"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005,8,9]]},"references-count":15,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2005,12]]}},"alternative-id":["10.1002\/mds.20646"],"URL":"https:\/\/doi.org\/10.1002\/mds.20646","archive":["Portico"],"relation":{},"ISSN":["0885-3185","1531-8257"],"issn-type":[{"value":"0885-3185","type":"print"},{"value":"1531-8257","type":"electronic"}],"subject":[],"published":{"date-parts":[[2005,8,9]]}}}