{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T06:01:08Z","timestamp":1791352868576,"version":"4.3.1"},"reference-count":48,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2005,8,26]],"date-time":"2005-08-26T00:00:00Z","timestamp":1125014400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Movement Disorders"],"published-print":{"date-parts":[[2006,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Enkephalin is reported to play an important role in the pathophysiology of levodopa (LD) \u2010induced dyskinesias. The present study investigated the effect of chronic treatment with a selective NR1A\/2B <jats:italic>N<\/jats:italic>\u2010methyl\u2010<jats:sc>D<\/jats:sc>\u2010aspartate (NMDA) receptor antagonist, CI\u20101041, on the expression of preproenkephalin\u2010A (PPE\u2010A) in brains of 1\u2010methyl\u20104\u2010phenyl\u20101,2,3,6\u2010tetrahydropyridine (MPTP) \u2010treated monkeys in relation to the development of LD\u2010induced dyskinesias. Four MPTP\u2010monkeys received LD\/benserazide alone; they all developed dyskinesias. Four other MPTP\u2010monkeys received LD\/benserazide plus CI\u20101041; only one of them developed mild dyskinesias at the end of the fourth week of treatment. Four normal monkeys and four saline\u2010treated MPTP monkeys were also included. MPTP\u2010treated monkeys had extensive and similar striatal dopamine denervation. An increase of PPE\u2010A mRNA levels assayed by in situ hybridization was observed in the lateral putamen (rostral and caudal) and caudate nucleus (rostral) of saline\u2010treated MPTP monkeys compared to controls, whereas no change or a small increase was observed in their medial parts. Striatal PPE\u2010A mRNA levels remained elevated in LD\u2010treated MPTP monkeys, whereas cotreatment with CI\u20101041 brought them back to control values. These findings suggest that chronic blockade of striatal NR1A\/2B NMDA receptors with CI\u20101041 normalizes PPE\u2010A mRNA expression and prevents the development of LD\u2010induced dyskinesias in an animal model of Parkinson disease. \u00a9 2005 Movement Disorder Society<\/jats:p>","DOI":"10.1002\/mds.20654","type":"journal-article","created":{"date-parts":[[2005,8,26]],"date-time":"2005-08-26T18:16:30Z","timestamp":1125080190000},"page":"9-17","source":"Crossref","is-referenced-by-count":55,"title":["Prevention of levodopa\u2010induced dyskinesias by a selective NR1A\/2B <i>N<\/i>\u2010methyl\u2010<scp>D<\/scp>\u2010aspartate receptor antagonist in parkinsonian monkeys: Implication of 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