{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T02:46:46Z","timestamp":1790477206416,"version":"4.1.0"},"reference-count":28,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2005,9,13]],"date-time":"2005-09-13T00:00:00Z","timestamp":1126569600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Movement Disorders"],"published-print":{"date-parts":[[2006,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>This study aimed to determine in vivo the atrophy patterns in clinically established cerebellar variant of multiple\u2010system atrophy (MSA\u2010C) using voxel\u2010based morphometry (VBM). Thirteen patients with MSA\u2010C (12 probable, 1 possible) and 13 healthy controls matched for age and sex were included. High\u2010resolution MR images were acquired with a 1.5 T scanner. Images were normalized onto a study\u2010specific template, segmented into the tissue compartments, modulated with the Jacobian determinants, and finally smoothed with a Gaussian kernel filter of 10 mm. The general linear model was used to assess statistical differences in gray and white matter. Infratentorial atrophy was observed in the cerebellar hemispheres, vermis, mesencephalon, and pons of MSA\u2010C patients. Supratentorial volume loss was found in orbitofrontal and mid\u2010frontal regions as well as in temporomesial and insular areas of both hemispheres. A negative correlation was observed between a cerebellar ataxia score and the volume of cerebellar hemispheres, peduncles, and pons. To compare this atrophy pattern to that of spinocerebellar ataxia (SCA2), which was previously reported by our group, a conjunction analysis was assessed. We observed a volume loss shared by both disorders comprising the cerebellum, vermis, pons, mesencephalon, orbitofrontal, mid\u2010frontal, and temporomesial cortex of both hemispheres as well as the left insular cortex. \u00a9 2005 Movement Disorder Society<\/jats:p>","DOI":"10.1002\/mds.20656","type":"journal-article","created":{"date-parts":[[2006,2,9]],"date-time":"2006-02-09T19:22:30Z","timestamp":1139512950000},"page":"159-165","source":"Crossref","is-referenced-by-count":58,"title":["Cortical atrophy in the cerebellar variant of multiple system atrophy: A voxel\u2010based morphometry study"],"prefix":"10.1002","volume":"21","author":[{"given":"Christian","family":"Brenneis","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sylvia M.","family":"Boesch","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karl E.","family":"Egger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Klaus","family":"Seppi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christoph","family":"Scherfler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Schocke","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gregor 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