{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,9]],"date-time":"2026-06-09T00:27:13Z","timestamp":1780964833294,"version":"3.54.1"},"reference-count":26,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2005,10,14]],"date-time":"2005-10-14T00:00:00Z","timestamp":1129248000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Movement Disorders"],"published-print":{"date-parts":[[2006,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>There is a need for new medication for essential tremor (ET). Preliminary evidence suggests that amantadine may be effective in the treatment of ET. We studied the effects of amantadine in a double\u2010blind, cross\u2010over, placebo\u2010controlled trial in ET patients. Sixteen patients with ET received amantadine 100 mg b.i.d. and placebo for 15 days, with a 1\u2010week wash\u2010out period between treatments. Major evaluation outcomes consisted of a tremor clinical rating scale, accelerometric recordings, and a self\u2010reported disability scale obtained before drug intake and on study days 1 and 15 of each treatment period. A two\u2010way repeated measures analysis of variance (treatment, time) was applied. Any <jats:italic>P<\/jats:italic> value &lt; 0.05 was considered significant. On day 15, amantadine did not demonstrate any significant efficacy in reducing tremor with respect to baseline in any tremor measures. An increase in postural tremor as an adverse effect of amantadine was referred by 37.5% of patients. Results from the present trial indicate amantadine at 100 mg b.i.d. is not effective as a treatment for ET. \u00a9 2005 Movement Disorder Society<\/jats:p>","DOI":"10.1002\/mds.20676","type":"journal-article","created":{"date-parts":[[2005,10,14]],"date-time":"2005-10-14T18:18:14Z","timestamp":1129313894000},"page":"441-445","source":"Crossref","is-referenced-by-count":18,"title":["Effect of amantadine in essential tremor: A randomized, placebo\u2010controlled trial"],"prefix":"10.1002","volume":"21","author":[{"given":"Alexandre","family":"Gironell","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jaime","family":"Kulisevsky","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Berta","family":"Pascual\u2010Sedano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Flamarich","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2005,10,14]]},"reference":[{"key":"e_1_2_5_2_2","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.57.10.1522"},{"key":"e_1_2_5_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0025-7753(01)72193-8"},{"key":"e_1_2_5_4_2","doi-asserted-by":"publisher","DOI":"10.1097\/00002826-198912000-00001"},{"key":"e_1_2_5_5_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM197405022901802"},{"key":"e_1_2_5_6_2","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.44.7.650"},{"key":"e_1_2_5_7_2","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.49.1.64"},{"key":"e_1_2_5_8_2","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1111\/j.1742-1241.2001.tb11012.x","article-title":"Managing influenza: amantadine, rimantadine and beyond","volume":"55","author":"Fleming DM","year":"2001","journal-title":"Int J Clin Pract"},{"key":"e_1_2_5_9_2","doi-asserted-by":"publisher","DOI":"10.1097\/00002826-198908000-00003"},{"key":"e_1_2_5_10_2","first-page":"893","article-title":"Amantadine and fatigue of multiple sclerosis","volume":"27","author":"Kemp BA","year":"1993","journal-title":"Ann Pharmacother"},{"key":"e_1_2_5_11_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.52.3.673-c"},{"key":"e_1_2_5_12_2","doi-asserted-by":"publisher","DOI":"10.1002\/mds.870130520"},{"key":"e_1_2_5_13_2","first-page":"91","article-title":"Amantadine and memantine are NMDA receptor antagonsits with neuroprotective properties","volume":"43","author":"Kornhuber J","year":"1994","journal-title":"J Neural Transm Suppl"},{"key":"e_1_2_5_14_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.46.6.1551"},{"key":"e_1_2_5_15_2","first-page":"233","volume-title":"Therapy of Parkinson's disease","author":"Kulisevsky J","year":"2004"},{"key":"e_1_2_5_16_2","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.35.3.365"},{"key":"e_1_2_5_17_2","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410090219"},{"key":"e_1_2_5_18_2","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410160517"},{"key":"e_1_2_5_19_2","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410190125"},{"issue":"3","key":"e_1_2_5_20_2","first-page":"2","article-title":"Consensus statement of the Movement Disorder Society on tremor","volume":"13","author":"Deuschl G","year":"1998","journal-title":"Mov Disord"},{"key":"e_1_2_5_21_2","doi-asserted-by":"publisher","DOI":"10.1097\/00004691-200411000-00009"},{"key":"e_1_2_5_22_2","unstructured":"World Medical Assembly.Recommendations guiding physicians in biomedical research involving human subjects. In: XVIII World Medical Assembly Helsinki June 1964 and XLI World Medical Assembly Hong Kong September 1989."},{"key":"e_1_2_5_23_2","first-page":"225","volume-title":"Parkinson's disease and movement disorders","author":"Fahn S","year":"1988"},{"key":"e_1_2_5_24_2","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.56.4.475"},{"key":"e_1_2_5_25_2","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.56.8.868"},{"key":"e_1_2_5_26_2","doi-asserted-by":"publisher","DOI":"10.1016\/0014-2999(89)90385-3"},{"key":"e_1_2_5_27_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1098-2396(19991215)34:4<313::AID-SYN7>3.0.CO;2-1"}],"container-title":["Movement Disorders"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fmds.20676","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/movementdisorders.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/mds.20676","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T08:57:22Z","timestamp":1760950642000},"score":1,"resource":{"primary":{"URL":"https:\/\/movementdisorders.onlinelibrary.wiley.com\/doi\/10.1002\/mds.20676"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005,10,14]]},"references-count":26,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2006,4]]}},"alternative-id":["10.1002\/mds.20676"],"URL":"https:\/\/doi.org\/10.1002\/mds.20676","archive":["Portico"],"relation":{},"ISSN":["0885-3185","1531-8257"],"issn-type":[{"value":"0885-3185","type":"print"},{"value":"1531-8257","type":"electronic"}],"subject":[],"published":{"date-parts":[[2005,10,14]]}}}