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All Olmsted County, Minnesota, residents with incident PD in 1976\u20131995 (n = 197) plus one age\u2010 and sex\u2010matched non\u2010PD referent subject per case were followed for all clinical diagnoses from 5 years before through 15 years after index (i.e., year of PD onset for each case and same year for the referent subject). Both members of a case\u2013referent pair were censored at death or emigration of either member to ensure equivalent follow\u2010up. Cases and referent subjects were compared for summary comorbidity (Charlson index) and for the likelihood of having one or more diagnoses within each International Classification of Diseases chapter\/subchapter. Before index, the groups were similar for all comparisons. After index, cases had a higher likelihood of diagnoses within the chapters \u201cMental Disorders\u201d and \u201cDiseases of the Genitourinary System,\u201d and within the subchapters \u201cOrganic Psychotic Conditions,\u201d \u201cOther Psychoses,\u201d \u201cNeurotic\/Personality\/Other Nonpsychotic Disorders,\u201d \u201cHereditary\/Degenerative Diseases of Central Nervous System,\u201d \u201cSymptoms,\u201d \u201cOther Diseases of Digestive System,\u201d \u201cOther Diseases of Urinary System,\u201d \u201cDiseases of Veins\/Lymphatics\/Other Circulatory System Diseases,\u201d \u201cFractures of Lower Limb,\u201d \u201cOther Diseases of Skin\/Subcutaneous Tissue,\u201d \u201cOsteopathies\/Chrondropathies\/Acquired Musculoskeletal Deformities,\u201d and \u201cPneumonia and Influenza.\u201d The excess morbidity and mortality observed for persons with PD are consistent with recognized PD sequelae. \u00a9 2005 Movement Disorder 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