{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,16]],"date-time":"2026-05-16T04:47:51Z","timestamp":1778906871113,"version":"3.51.4"},"reference-count":14,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2005,10,6]],"date-time":"2005-10-06T00:00:00Z","timestamp":1128556800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Movement Disorders"],"published-print":{"date-parts":[[2006,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Deep brain stimulation (DBS) is an established therapy for essential tremor (ET), but loss of efficacy due to tolerance can occur. Our objective was to evaluate if it is feasible to use DBS only on\u2010demand and if this would prevent tolerance. We report on the effects of left\u2010side thalamic DBS in 4 ET patients who were instructed to switch on stimulation only when using their right hand for motor tasks and were followed\u2010up to 30 months after surgery. The patients were capable of using DBS only on\u2010demand (DBS use of 22.0 \u00b1 13.5%\/day). DBS led to a stable suppression of right arm tremor throughout the follow\u2010up. No problems associated with tolerance such as tremor rebound or late therapy failure occurred. In comparison to publications stating that ET patients had been using DBS continuously during the daytime, the use of on\u2010demand DBS saves battery life, which delays surgical replacement of the stimulator. Thus, on\u2010demand DBS saves money, may help to prevent tolerance, and should be adopted for the long\u2010term treatment of ET patients. \u00a9 2005 Movement Disorder Society<\/jats:p>","DOI":"10.1002\/mds.20714","type":"journal-article","created":{"date-parts":[[2005,10,6]],"date-time":"2005-10-06T20:46:43Z","timestamp":1128631603000},"page":"401-405","source":"Crossref","is-referenced-by-count":42,"title":["On\u2010demand deep brain stimulation for essential tremor: A report on four cases"],"prefix":"10.1002","volume":"21","author":[{"given":"Martin","family":"Kronenbuerger","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christoph","family":"Fromm","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Frank","family":"Block","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Volker A.","family":"Coenen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ina","family":"Rohde","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Veit","family":"Rohde","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Johannes","family":"Noth","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,3,9]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.3171\/jns.1996.84.2.0203"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.66.3.289"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1159\/000029728"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1002\/mds.10309"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1002\/mds.1089"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.74.10.1387"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1007\/s004150170127"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1212\/01.WNL.0000096012.07360.1C"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.50.4.1184"},{"issue":"3","key":"e_1_2_6_11_2","first-page":"2","article-title":"Consensus statement of the Movement Disorder Society on Tremor","volume":"13","author":"Deuschl G","year":"1998","journal-title":"Mov Disord"},{"key":"e_1_2_6_12_2","first-page":"271","volume-title":"Parkinson\u2032s disease and movement disorders","author":"Fahn S","year":"1988"},{"key":"e_1_2_6_13_2","doi-asserted-by":"publisher","DOI":"10.3171\/jns.2000.93.1.0140"},{"key":"e_1_2_6_14_2","unstructured":"Medtronic \u201cBattery Lifetime \u2013 Reference Information\u201d. 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