{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T15:50:38Z","timestamp":1787241038465,"version":"build-2736575974"},"reference-count":16,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2005,11,2]],"date-time":"2005-11-02T00:00:00Z","timestamp":1130889600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Movement Disorders"],"published-print":{"date-parts":[[2006,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    We describe a patient with a combination of dystonic and parkinsonian signs. Paraclinical studies revealed a mutation in the GTP cyclohydrolase I gene (\n                    <jats:italic>GCH1<\/jats:italic>\n                    ) and a decrease in [\n                    <jats:sup>123<\/jats:sup>\n                    I]\u2010N\u2010\u03c9\u2010fluoropropyl\u20102\u03b2\u2010carbomethoxy\u20103\u03b2\u2010(4\u2010iodophenyl) nortropane (\n                    <jats:sup>123<\/jats:sup>\n                    I\u2010FP\u2010CIT) binding ratios indicative of Parkinson's disease. We conclude that the patient probably suffers from a variant of dopa\u2010responsive dystonia (DRD) or two separate movement disorders, normally considered to be differential diagnoses, DRD and early\u2010onset Parkinson's disease with resulting difficulties concerning treatment and prognosis. \u00a9 2005 Movement Disorder Society\n                  <\/jats:p>","DOI":"10.1002\/mds.20773","type":"journal-article","created":{"date-parts":[[2005,11,2]],"date-time":"2005-11-02T19:16:54Z","timestamp":1130959014000},"page":"679-682","source":"Crossref","is-referenced-by-count":35,"title":["Dopa\u2010responsive dystonia and early\u2010onset Parkinson's disease in a patient with GTP cyclohydrolase I deficiency?"],"prefix":"10.1002","volume":"21","author":[{"given":"Lena Elisabeth","family":"Hjermind","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lis Gitte","family":"Johannsen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nenad","family":"Blau","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ron Allan","family":"Wevers","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christoph\u2010Burkhard","family":"Lucking","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jens Michael","family":"Hertz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lars","family":"Friberg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lisbeth","family":"Regeur","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J\u00f8rgen Erik","family":"Nielsen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sven Asger","family":"S\u00f8rensen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2005,11,2]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410440411"},{"key":"e_1_2_6_3_2","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1093\/clinchem\/47.3.477","article-title":"Diagnosis of dopa\u2010responsive dystonia and other tetrahydrobiopterin disorders by study of biopterin metabolism in fibroblasts","volume":"47","author":"Bonaf\u00e9 L","year":"2001","journal-title":"Clin Chem"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1093\/clinchem\/44.9.1897"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM200005253422103"},{"key":"e_1_2_6_6_2","unstructured":"HertzJM OstergaardK JunckerI et al.Mutation analysis of the Parkin (PARK2) the Tyrosine Hydroxylase (TH) and the GTP Cyclohydrolase I (GCH1) genes in a Danish population of early\u2010onset Parkinson's Disease. 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Clinical and biochemical differences from hereditary progressive dystonia or dopa\u2010responsive dystonia","volume":"69","author":"Furukawa Y","year":"1996","journal-title":"Adv Neurol"},{"key":"e_1_2_6_12_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00415-002-0776-3"},{"key":"e_1_2_6_13_2","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410430614"},{"key":"e_1_2_6_14_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.41.2_Part_1.174"},{"key":"e_1_2_6_15_2","first-page":"216","article-title":"Drug\u2010induced motor complications in dopa\u2010responsive dystonia: implications for the pathogenesis of dyskinesias and motor fluctuations","volume":"22","author":"de la Fuente\u2010Fernandez R","year":"1999","journal-title":"Clin Neuropharmacol"},{"key":"e_1_2_6_16_2","doi-asserted-by":"publisher","DOI":"10.1002\/mds.10712"},{"key":"e_1_2_6_17_2","doi-asserted-by":"publisher","DOI":"10.1002\/mds.10478"}],"container-title":["Movement Disorders"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fmds.20773","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/movementdisorders.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/mds.20773","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T11:14:15Z","timestamp":1760958855000},"score":1,"resource":{"primary":{"URL":"https:\/\/movementdisorders.onlinelibrary.wiley.com\/doi\/10.1002\/mds.20773"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005,11,2]]},"references-count":16,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2006,5]]}},"alternative-id":["10.1002\/mds.20773"],"URL":"https:\/\/doi.org\/10.1002\/mds.20773","archive":["Portico"],"relation":{},"ISSN":["0885-3185","1531-8257"],"issn-type":[{"value":"0885-3185","type":"print"},{"value":"1531-8257","type":"electronic"}],"subject":[],"published":{"date-parts":[[2005,11,2]]}}}