{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T12:49:10Z","timestamp":1788871750683,"version":"build-2803163510"},"reference-count":23,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2006,4,6]],"date-time":"2006-04-06T00:00:00Z","timestamp":1144281600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001349","name":"National Medical Research Council","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100001349","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100012415","name":"Biomedical Research Council","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100012415","id-type":"DOI","asserted-by":"crossref"}]},{"name":"SingHealth"},{"DOI":"10.13039\/501100005606","name":"Genome Institute of Singapore","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100005606","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Movement Disorders"],"published-print":{"date-parts":[[2006,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    The pleomorphic pathology of postmortem\n                    <jats:italic>LRRK2<\/jats:italic>\n                    \u2010positive patients and the frequent association with late\u2010onset Parkinson's disease (LOPD) symptoms suggest that\n                    <jats:italic>LRRK2<\/jats:italic>\n                    mutations may play a role in Parkinson's Plus disorders and LOPD. Published studies primarily focus on the common G2019S mutation. Analysis of a spectrum of\n                    <jats:italic>LRRK2<\/jats:italic>\n                    mutations in Parkinson's Plus disorders has yet to be reported. We investigated 14 leucine\u2010rich repeat kinase 2 (LRRK2) mutations in a cohort of Parkinson's Plus disorders and LOPD. A total of 458 patients with progressive supranuclear palsy (PSP), multiple system atrophy (MSA), corticobasal ganglionic degeneration (CBGD), atypical Parkinsonism (AP), and LOPD were screened for 14 mutations that span exons 19 to 41 of the\n                    <jats:italic>LRRK2<\/jats:italic>\n                    gene. Among the LOPD cases, 1 patient was found to harbor the R1441C mutation. He presented with typical features of PD at age of 58 years old and responded well to levodopa. We did not detect any of the 14 mutations in PSP, MSA, CBGD, and AP patients. We highlight the first case of\n                    <jats:italic>LRRK2<\/jats:italic>\n                    R1441C mutation in late onset sporadic PD of non\u2010European ancestry. Furthermore, extensive mutational screen found\n                    <jats:italic>LRRK2<\/jats:italic>\n                    mutations to be rare among patients who presented with PSP, MSA, CBGD, and AP. \u00a9 2006 Movement Disorder Society\n                  <\/jats:p>","DOI":"10.1002\/mds.20875","type":"journal-article","created":{"date-parts":[[2006,4,6]],"date-time":"2006-04-06T17:51:15Z","timestamp":1144345875000},"page":"997-1001","source":"Crossref","is-referenced-by-count":53,"title":["Analysis of 14 LRRK2 mutations in Parkinson's plus syndromes and late\u2010onset Parkinson's disease"],"prefix":"10.1002","volume":"21","author":[{"given":"E.K.","family":"Tan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lisa","family":"Skipper","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eva","family":"Chua","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meng\u2010Cheong","family":"Wong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ratnagopal","family":"Pavanni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carine","family":"Bonnard","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Prasanna","family":"Kolatkar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jian\u2010Jun","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2006,4,6]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1042\/BST0330586"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.55.4.533"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00439-005-0038-4"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2004.11.005"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2004.10.023"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(05)17829-5"},{"key":"e_1_2_6_8_2","first-page":"415","article-title":"A common LRRK2 mutation in idiopathic Parkinson's disease","volume":"365","author":"Gilks WP","year":"2005","journal-title":"Lancet"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1002\/ana.10113"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.1212\/01.wnl.0000180517.70572.37"},{"key":"e_1_2_6_11_2","first-page":"384","article-title":"The G2019S LRRK2 mutation is uncommon in an Asian cohort of Parkinson's disease patients","volume":"26","author":"Tan EK","year":"2005","journal-title":"Neurosci 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