{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,11]],"date-time":"2026-08-11T19:32:05Z","timestamp":1786476725050,"version":"build-2736575974"},"reference-count":17,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2006,5,16]],"date-time":"2006-05-16T00:00:00Z","timestamp":1147737600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2006,5,16]],"date-time":"2006-05-16T00:00:00Z","timestamp":1147737600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Movement Disorders"],"published-print":{"date-parts":[[2006,9]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Based on its action on multiple neurotransmitters, including dopamine, methylphenidate (MPH) is of growing interest as a possible treatment option for several movement disorders. Of special interest are diseases that share gait disturbance and cognitive decline. Based on a single case observation in a patient with hereditary spastic spinal paraplegia (HSP) in which gait was improved with MPH, we performed an open\u2010label study with a longitudinal follow\u2010up in 22 patients with HSP and its sporadic form (SSP). The patients were treated for 6 months with 60 mg of MPH per day. Computerized gait analysis and different scores were performed at baseline, after 6 weeks, and after 6 months of treatment. Although at 6 weeks, the gait velocity was somewhat improved, the drug failed to show any effect on other gait parameters and had no beneficial effect at all after 6 months. Although MPH is of interest for several movement disorders, our study did not show a beneficial effect. \u00a9 2006 Movement Disorder Society<\/jats:p>","DOI":"10.1002\/mds.20973","type":"journal-article","created":{"date-parts":[[2006,5,16]],"date-time":"2006-05-16T16:00:08Z","timestamp":1147795208000},"page":"1468-1471","source":"Crossref","is-referenced-by-count":10,"title":["Methylphenidate fails to improve gait and muscle tone in patients with sporadic and hereditary spastic paraplegia"],"prefix":"10.1002","volume":"21","author":[{"given":"Stephan","family":"Klebe","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G\u00fcnther","family":"Deuschl","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Henning","family":"Stolze","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2006,5,16]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF02224539"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1002\/ana.20416"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1186\/1744-9081-1-2"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.braindev.2004.11.009"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.npp.1300839"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.2165\/00023210-200317150-00004"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-132-6-200003210-00023"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00415-004-0366-7"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.69.2.150"},{"key":"e_1_2_6_11_2","doi-asserted-by":"publisher","DOI":"10.1093\/ptj\/67.2.206"},{"key":"e_1_2_6_12_2","series-title":"Aids to the examination of the peripheral nervous system","author":"Medical Research Council","year":"1976"},{"key":"e_1_2_6_13_2","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/124.11.2278"},{"key":"e_1_2_6_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(89)80759-0"},{"key":"e_1_2_6_15_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.93.19.10388"},{"key":"e_1_2_6_16_2","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/S0022-3565(24)38868-8","article-title":"Comparison between intraperitoneal and oral methylphenidate administration: a microdialysis and locomotor activity study","volume":"295","author":"Gerasimov MR","year":"2000","journal-title":"J Pharmacol Exp Ther"},{"key":"e_1_2_6_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0361-9230(99)00268-3"},{"issue":"1","key":"e_1_2_6_18_2","first-page":"15.33","article-title":"Methylphenidate treatment improves cognitive function and gait performance in patients with Parkinson's disease","volume":"21","author":"Urihel E","year":"2005","journal-title":"Gait Posture"}],"container-title":["Movement Disorders"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fmds.20973","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/movementdisorders.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/mds.20973","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/movementdisorders.onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/mds.20973","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/movementdisorders.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/mds.20973","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,11]],"date-time":"2026-08-11T19:12:11Z","timestamp":1786475531000},"score":1,"resource":{"primary":{"URL":"https:\/\/movementdisorders.onlinelibrary.wiley.com\/doi\/10.1002\/mds.20973"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,5,16]]},"references-count":17,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2006,9]]}},"alternative-id":["10.1002\/mds.20973"],"URL":"https:\/\/doi.org\/10.1002\/mds.20973","archive":["Portico"],"relation":{},"ISSN":["0885-3185","1531-8257"],"issn-type":[{"value":"0885-3185","type":"print"},{"value":"1531-8257","type":"electronic"}],"subject":[],"published":{"date-parts":[[2006,5,16]]}}}