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To assess dopaminergic function in SCA1, 2, and 3, dopamine D<jats:sub>2<\/jats:sub> receptor binding potential (BP) was assessed by [<jats:sup>11<\/jats:sup>C]raclopride positron emission tomography in 10 SCA patients, 4 of whom suffered from RLS as demonstrated by polysomnography. BP was compared to 9 age\u2010matched control subjects. In 2 SCA patients, striatal BP was clearly reduced (&lt;2 SD below the mean of controls). However, there were no significant group differences between SCA and controls, largely owing to a significantly higher variance of striatal BP in SCA. BP was negatively correlated with disease duration. The fit suggests an increased BP in early stages, followed by a moderate decline in all quantified regions (caudate, dorsal putamen, ventral striatum) presumably reflecting a progressive loss of D<jats:sub>2<\/jats:sub> receptors. RLS in SCA was not accompanied by a significant reduction of D<jats:sub>2<\/jats:sub> receptor availability in the striatum. This missing correlation may point to an extrastriatal origin of RLS. \u00a9 2006 Movement Disorder Society<\/jats:p>","DOI":"10.1002\/mds.20978","type":"journal-article","created":{"date-parts":[[2006,8,28]],"date-time":"2006-08-28T18:51:05Z","timestamp":1156791065000},"page":"1667-1673","source":"Crossref","is-referenced-by-count":31,"title":["Spinocerebellar ataxia type 1, 2, and 3 and restless legs syndrome: Striatal dopamine D2 receptor status investigated by [<sup>11<\/sup>C]raclopride positron emission 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