{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T09:22:07Z","timestamp":1791105727871,"version":"4.1.0"},"reference-count":74,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2006,9,7]],"date-time":"2006-09-07T00:00:00Z","timestamp":1157587200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Movement Disorders"],"published-print":{"date-parts":[[2006,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Investigation of the pathophysiology of psychosis in Parkinson's disease (PD), as well as the assessment of potential novel therapeutics, has been limited by the lack of a well\u2010validated animal model. MPTP\u2010lesioned primates exhibit abnormal behaviors that are distinct from dyskinesia and parkinsonism and may represent behavioral correlates of neural processes related to psychosis in PD. Here we assess four types of behavior\u2014agitation, hallucinatory\u2010like responses to nonapparent stimuli, obsessive grooming, and stereotypies that are termed \u201cpsychosis\u2010like\u201d\u2014and define their pharmacology using a psychosis\u2010like behavior rating scale. By assessing the actions of drugs known to enhance or attenuate psychosis in PD patients, we find that the pharmacology of these behaviors recapitulates, in several respects, the pharmacology of psychosis in PD. Thus, levodopa and apomorphine elicited psychosis\u2010like behaviors. Amantadine significantly decreased levodopa\u2010induced dyskinesia but exacerbated psychosis\u2010like behaviors. Haloperidol reduced psychosis\u2010like behaviors but at the expense of increased parkinsonian disability while the atypical neuroleptics clozapine and quetiapine reduced psychosis\u2010like behaviors without significant effect on parkinsonian disability. The response of different components of the psychotomimetic behavior suggested the involvement of both dopaminergic and nondopaminergic mechanisms in their expression. \u00a9 2006 Movement Disorder Society<\/jats:p>","DOI":"10.1002\/mds.21073","type":"journal-article","created":{"date-parts":[[2006,9,7]],"date-time":"2006-09-07T13:53:17Z","timestamp":1157637197000},"page":"1879-1891","source":"Crossref","is-referenced-by-count":88,"title":["Pharmacological characterization of psychosis\u2010like behavior in the MPTP\u2010lesioned nonhuman primate model of Parkinson's disease"],"prefix":"10.1002","volume":"21","author":[{"given":"Naomi P.","family":"Visanji","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jordi","family":"Gomez\u2010Ramirez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tom 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