{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,5]],"date-time":"2026-08-05T05:25:05Z","timestamp":1785907505372,"version":"3.56.0"},"reference-count":17,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2006,9,21]],"date-time":"2006-09-21T00:00:00Z","timestamp":1158796800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Movement Disorders"],"published-print":{"date-parts":[[2006,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>We report on a young woman who survived acute liver failure (ALF) without liver transplant. During the ALF, she developed a disabling, levodopa\u2010unresponsive, symmetrical Parkinsonism. This was characterized by severe bradykinesia, mild rigidity, mutism, and prominent gait impairment. Magnetic resonance imaging (MRI) showed bilateral T1W pallidal hyperintensities. Parkinsonism and MRI changes remitted in parallel with normalization of hepatic function. We implicate excessive pallidal manganese deposition secondary to ALF in the pathogenesis of this neuroradiological syndrome. Though hitherto unreported, we propose that Parkinsonism with T1W pallidal hyperintensities may not be uncommon in ALF. \u00a9 2006 Movement Disorder Society<\/jats:p>","DOI":"10.1002\/mds.21096","type":"journal-article","created":{"date-parts":[[2006,9,21]],"date-time":"2006-09-21T18:55:46Z","timestamp":1158864946000},"page":"1986-1990","source":"Crossref","is-referenced-by-count":25,"title":["Reversible Parkinsonism and T1W pallidal hyperintensities in acute liver failure"],"prefix":"10.1002","volume":"21","author":[{"given":"Annu","family":"Aggarwal","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sachin","family":"Vaidya","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samir","family":"Shah","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joshita","family":"Singh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shrinivas","family":"Desai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohit","family":"Bhatt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2006,9,21]]},"reference":[{"key":"e_1_2_4_2_2","doi-asserted-by":"publisher","DOI":"10.1002\/hep.20703"},{"key":"e_1_2_4_3_2","first-page":"111","volume-title":"Drug Induced Movement Disorders","author":"Bhatt M","year":"2004"},{"key":"e_1_2_4_4_2","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410370616"},{"issue":"3","key":"e_1_2_4_5_2","first-page":"22","article-title":"Central pontine and extrapontine myelinolysis: the osmotic demyelination syndromes","volume":"75","author":"Martin RJ","year":"2004","journal-title":"J Neurol Neurosurg Psychiatry"},{"key":"e_1_2_4_6_2","first-page":"773","volume-title":"Magnetic Resonance Imaging of Brain and Spine","author":"Scott AW","year":"2002"},{"key":"e_1_2_4_7_2","doi-asserted-by":"publisher","DOI":"10.1002\/mds.10650"},{"key":"e_1_2_4_8_2","doi-asserted-by":"publisher","DOI":"10.1212\/01.wnl.0000178224.81169.c2"},{"key":"e_1_2_4_9_2","first-page":"170","article-title":"Hemichorea\u2010hemiballism associated with hyperintense putamen on T1\u2010weighted MR images: an update and a hypothesis","volume":"13","author":"Shan DE","year":"2004","journal-title":"Acta Neurol Taiwan"},{"key":"e_1_2_4_10_2","doi-asserted-by":"publisher","DOI":"10.1002\/hep.1840160613"},{"key":"e_1_2_4_11_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1525-1373.1999.d01-120.x"},{"key":"e_1_2_4_12_2","doi-asserted-by":"publisher","DOI":"10.1007\/s002340050464"},{"key":"e_1_2_4_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-510X(98)00289-5"},{"key":"e_1_2_4_14_2","first-page":"217","volume-title":"Intoxications of the Nervous System: Part 1","author":"Mena I","year":"1979"},{"key":"e_1_2_4_15_2","first-page":"303","volume-title":"Intoxications of the Nervous System: Part 1","author":"Feldman RG","year":"1994"},{"issue":"2","key":"e_1_2_4_16_2","first-page":"11","article-title":"Pathogenesis of hepatic encephalopathy: update on molecular mechanisms","volume":"22","author":"Butterworth RF","year":"2003","journal-title":"Ind J Gastroenterol"},{"key":"e_1_2_4_17_2","doi-asserted-by":"publisher","DOI":"10.1097\/00005072-196301000-00011"},{"key":"e_1_2_4_18_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.60.3.519"}],"container-title":["Movement Disorders"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fmds.21096","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/movementdisorders.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/mds.21096","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T11:02:53Z","timestamp":1760958173000},"score":1,"resource":{"primary":{"URL":"https:\/\/movementdisorders.onlinelibrary.wiley.com\/doi\/10.1002\/mds.21096"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,9,21]]},"references-count":17,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2006,11]]}},"alternative-id":["10.1002\/mds.21096"],"URL":"https:\/\/doi.org\/10.1002\/mds.21096","archive":["Portico"],"relation":{},"ISSN":["0885-3185","1531-8257"],"issn-type":[{"value":"0885-3185","type":"print"},{"value":"1531-8257","type":"electronic"}],"subject":[],"published":{"date-parts":[[2006,9,21]]}}}