{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T06:45:27Z","timestamp":1791096327898,"version":"4.1.0"},"reference-count":15,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2006,9,29]],"date-time":"2006-09-29T00:00:00Z","timestamp":1159488000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Movement Disorders"],"published-print":{"date-parts":[[2006,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>We aimed to evaluate the potential of the cerebrospinal fluid (CSF) axonal damage biomarker NfH<jats:sup>SMI35<\/jats:sup> in the laboratory\u2010supported differential diagnosis of parkinsonian syndromes. Patients with idiopathic Parkinson's disease (PD; n = 22), multiple\u2010system atrophy (MSA; n = 21), progressive supranuclear palsy (PSP; n = 21), corticobasal degeneration (CBD; n = 6), and age\u2010matched controls (n = 45) were included. CSF levels of NfH<jats:sup>SMI35<\/jats:sup> were measured using ELISA. Levels of CSF NfH<jats:sup>SMI35<\/jats:sup> were elevated in PSP compared to PD and controls (<jats:italic>P<\/jats:italic> &lt; 0.05 each). They were also significantly higher in MSA than in PD and controls (<jats:italic>P<\/jats:italic> &lt; 0.05 each). NfH<jats:sup>SMI35<\/jats:sup> differentiated PD from PSP with a sensitivity of 76.5% and a specificity of 94.4%. Axonal damage as measured by CSF NfH<jats:sup>SMI35<\/jats:sup> is most prominent in the more rapidly progressive syndromes PSP and MSA as compared to PD or CBD. CSF NfH<jats:sup>SMI35<\/jats:sup> may therefore be of some value for the laboratory\u2010supported differential diagnosis of atypical parkinsonian syndromes. \u00a9 2006 Movement Disorder Society<\/jats:p>","DOI":"10.1002\/mds.21124","type":"journal-article","created":{"date-parts":[[2006,9,29]],"date-time":"2006-09-29T17:27:15Z","timestamp":1159550835000},"page":"2224-2227","source":"Crossref","is-referenced-by-count":60,"title":["Neurofilament heavy\u2010chain NfH<sup>SMI35<\/sup> in cerebrospinal fluid supports the differential diagnosis of Parkinsonian syndromes"],"prefix":"10.1002","volume":"21","author":[{"given":"Johannes","family":"Brettschneider","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Axel","family":"Petzold","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sigurd D.","family":"S\u00fc\u00dfmuth","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Georg B.","family":"Landwehrmeyer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Albert C.","family":"Ludolph","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jan","family":"Kassubek","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hayrettin","family":"Tumani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2006,9,29]]},"reference":[{"key":"e_1_2_5_2_2","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awf080"},{"key":"e_1_2_5_3_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.47.1.1"},{"key":"e_1_2_5_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-1759(03)00189-3"},{"key":"e_1_2_5_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-510X(98)00304-9"},{"key":"e_1_2_5_6_2","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/120.1.65"},{"key":"e_1_2_5_7_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.48.1.119"},{"key":"e_1_2_5_8_2","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.55.3.181"},{"key":"e_1_2_5_9_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0404.2007.00818.x"},{"key":"e_1_2_5_10_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.17.5.427"},{"key":"e_1_2_5_11_2","first-page":"152","volume-title":"Third Symposium on Parkinson's Disease","author":"Schwab RS","year":"1969"},{"key":"e_1_2_5_12_2","doi-asserted-by":"publisher","DOI":"10.1212\/01.wnl.0000203120.85850.54"},{"key":"e_1_2_5_13_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(1950)3:1<32::AID-CNCR2820030106>3.0.CO;2-3"},{"key":"e_1_2_5_14_2","doi-asserted-by":"publisher","DOI":"10.1002\/mds.870130116"},{"key":"e_1_2_5_15_2","doi-asserted-by":"publisher","DOI":"10.1002\/cne.10096"},{"key":"e_1_2_5_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0304-3940(97)00215-2"}],"container-title":["Movement Disorders"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fmds.21124","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/movementdisorders.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/mds.21124","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T13:42:15Z","timestamp":1760967735000},"score":1,"resource":{"primary":{"URL":"https:\/\/movementdisorders.onlinelibrary.wiley.com\/doi\/10.1002\/mds.21124"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,9,29]]},"references-count":15,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2006,12]]}},"alternative-id":["10.1002\/mds.21124"],"URL":"https:\/\/doi.org\/10.1002\/mds.21124","archive":["Portico"],"relation":{},"ISSN":["0885-3185","1531-8257"],"issn-type":[{"value":"0885-3185","type":"print"},{"value":"1531-8257","type":"electronic"}],"subject":[],"published":{"date-parts":[[2006,9,29]]}}}