{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,10]],"date-time":"2026-01-10T23:31:25Z","timestamp":1768087885181,"version":"3.49.0"},"reference-count":29,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2006,10,16]],"date-time":"2006-10-16T00:00:00Z","timestamp":1160956800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Movement Disorders"],"published-print":{"date-parts":[[2006,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The objectives of this study is to examine the effects of neuromuscular therapy (NMT) on motor and nonmotor symptoms in Parkinson's disease (PD). Thirty\u2010six subjects with PD were randomly assigned to NMT or music relaxation (MR, or active control). Subjects received treatment twice a week for 4 weeks. Testing was conducted at baseline, after final treatment, and 8 days after final treatment. Primary outcome measures were the Motor subscale of the United Parkinson Disease Rating Scale (UPDRS) and the Clinical Global Impression scale (CGI\u2010Change). Secondary outcome measures included a PD\u2010specific quality of life scale (PDQ\u201039), quantitative measures of motor function, and severity scales for anxiety and depression symptoms. NMT resulted in a significant and sustained improvement in the Motor subscale of the UPDRS (<jats:italic>P<\/jats:italic> \u2264 0.0001), most notable in the tremor scores. Also improved 1 week after the last treatment were the CGI scores (<jats:italic>P<\/jats:italic> = 0.007) and the finger\u2010tapping speed (<jats:italic>P<\/jats:italic> = 0.001). The MR active control group had a slight improvement in tremor but evidenced no other change in motor function. Both groups exhibited a modest improvement in quality of life immediately after the last treatment. This effect was sustained for 8 days only in the MR group. In the nonmotor domains, the MR group evidenced improvements in mood (<jats:italic>P<\/jats:italic> = 0.001) and anxiety (<jats:italic>P<\/jats:italic> = 0.002), whereas NMT had no effect on mood (<jats:italic>P<\/jats:italic> = 0.09), and its initial effect on anxiety (<jats:italic>P<\/jats:italic> = 0.0009) dissipated after 8 days (<jats:italic>P<\/jats:italic> = 0.40). Group differences for UPDRS motor score and patient CGI\u2010Change were superior in the NMT compared to the MR group. There was no group difference in PDQ\u201039 scores or in nonmotor measures. The findings suggest that NMT can improve motor and selected nonmotor symptoms in PD and that this effect is more durable for the motor symptoms. The results of this pilot study warrant larger controlled studies to examine dose range, durability, and mechanisms of NMT in PD function. \u00a9 2006 Movement Disorder Society<\/jats:p>","DOI":"10.1002\/mds.21132","type":"journal-article","created":{"date-parts":[[2006,10,17]],"date-time":"2006-10-17T07:02:06Z","timestamp":1161068526000},"page":"2127-2133","source":"Crossref","is-referenced-by-count":38,"title":["Controlled pilot study of the effects of neuromuscular therapy in patients with Parkinson's disease"],"prefix":"10.1002","volume":"21","author":[{"given":"Lauren H.","family":"Craig","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anna","family":"Svircev","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael","family":"Haber","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jorge L.","family":"Juncos","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,10,16]]},"reference":[{"key":"e_1_2_6_2_2","first-page":"2406","volume-title":"Harrison's Principles of Internal Medicine","author":"DeLong MR","year":"2004"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1054\/ctim.2000.0366"},{"key":"e_1_2_6_4_2","first-page":"565","article-title":"Traditional and complementary therapies in Parkinson's disease","volume":"80","author":"Manyam BV","year":"1999","journal-title":"Adv Neurol"},{"key":"e_1_2_6_5_2","first-page":"34","article-title":"Parkinson's disease and massage therapy","volume":"35","author":"Miesler DW","year":"1996","journal-title":"Massage Therapy J"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.1983.01790060110016"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.17.5.427"},{"key":"e_1_2_6_8_2","volume-title":"Myofascial pain and dysfunction: the trigger point manual","author":"Travell J","year":"1983"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0404.2007.00818.x"},{"key":"e_1_2_6_10_2","first-page":"218","volume-title":"ECDEU assessment manual for psychopharmacology (revised edition)","author":"Guy W","year":"1976"},{"key":"e_1_2_6_11_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF02260863"},{"key":"e_1_2_6_12_2","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.1961.01710120031004"},{"key":"e_1_2_6_13_2","doi-asserted-by":"publisher","DOI":"10.1089\/acm.2000.6.405"},{"key":"e_1_2_6_14_2","doi-asserted-by":"publisher","DOI":"10.1037\/0003-066X.53.12.1270"},{"key":"e_1_2_6_15_2","first-page":"34","article-title":"Medical massage","volume":"29","author":"Gallia K","year":"1999","journal-title":"Natural Health"},{"key":"e_1_2_6_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1096-2190(99)00006-2"},{"key":"e_1_2_6_17_2","doi-asserted-by":"publisher","DOI":"10.1177\/089801019201000404"},{"key":"e_1_2_6_18_2","doi-asserted-by":"publisher","DOI":"10.1097\/00006842-200005000-00012"},{"key":"e_1_2_6_19_2","doi-asserted-by":"publisher","DOI":"10.1054\/jbmt.2002.0282"},{"key":"e_1_2_6_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0897-1897(95)80305-X"},{"key":"e_1_2_6_21_2","first-page":"529","article-title":"Massage and music therapies attenuate frontal EEG asymmetry in depressed adolescents","volume":"34","author":"Jones NA","year":"1999","journal-title":"Adolescence"},{"key":"e_1_2_6_22_2","first-page":"97","article-title":"Comparison of effects of spinal manipulation and massage on motoneuron excitability","volume":"41","author":"Dishman JD","year":"2001","journal-title":"Electromyogr Clin Neurophysiol"},{"key":"e_1_2_6_23_2","doi-asserted-by":"crossref","first-page":"1679","DOI":"10.1093\/ptj\/50.12.1679","article-title":"The influence of back massage on autonomic functions","volume":"50","author":"Barr JS","year":"1970","journal-title":"Phys Ther"},{"key":"e_1_2_6_24_2","doi-asserted-by":"crossref","first-page":"1213","DOI":"10.1001\/jama.1992.03480090061028","article-title":"The effects of nonpharmacologic interventions on blood pressure of persons with high normal levels. 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