{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T11:03:19Z","timestamp":1788433399002,"version":"build-2803163510"},"reference-count":23,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2006,11,28]],"date-time":"2006-11-28T00:00:00Z","timestamp":1164672000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Movement Disorders"],"published-print":{"date-parts":[[2007,1,15]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Dopaminergic imaging has been found to be normal in approximately 15% of parkinsonian patients enrolled in neuroprotective trials. We used <jats:sup>18<\/jats:sup>F\u2010fluorodeoxyglucose positron emission tomography (FDG PET) to determine the metabolic basis for this finding. We reviewed scans from 185 patients with clinical signs of Parkinson's disease (PD) who underwent <jats:sup>18<\/jats:sup>F\u2010fluorodopa PET imaging for diagnostic confirmation. Of this group, 27 patients (14.6%) had quantitatively normal scans; 8 of these patients were additionally scanned with FDG PET. Pattern analysis was performed on an individual scan basis to determine whether the metabolic changes were consistent with classic PD. Computer\u2010assisted single\u2010case assessments of the FDG PET scans of these 8 patients did not disclose patterns of regional metabolic change compatible with classical PD or an atypical parkinsonian variant. Similarly, network quantification revealed that PD\u2010related pattern expression was not elevated in these patients as it was in an age\u2010 and duration\u2010matched cohort with classical PD (<jats:italic>P<\/jats:italic> &lt; 0.0001). None of these patients developed clinical signs of classical PD or of an atypical parkinsonian syndrome at a follow\u2010up visit conducted 3 years after imaging. The results suggest that parkinsonian subjects with normal dopaminergic imaging do not have evidence of classical PD or an atypical parkinsonian syndrome. \u00a9 2006 Movement Disorder Society<\/jats:p>","DOI":"10.1002\/mds.21185","type":"journal-article","created":{"date-parts":[[2006,11,28]],"date-time":"2006-11-28T15:58:45Z","timestamp":1164729525000},"page":"167-173","source":"Crossref","is-referenced-by-count":45,"title":["Regional metabolic changes in Parkinsonian patients with normal dopaminergic imaging"],"prefix":"10.1002","volume":"22","author":[{"given":"Thomas","family":"Eckert","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew","family":"Feigin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel 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