{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,15]],"date-time":"2026-04-15T00:15:37Z","timestamp":1776212137837,"version":"3.50.1"},"reference-count":16,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2006,11,6]],"date-time":"2006-11-06T00:00:00Z","timestamp":1162771200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Movement Disorders"],"published-print":{"date-parts":[[2007,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>We studied the relationship between two screening cognitive measures and <jats:italic>off<\/jats:italic> motor Unified Parkinson's Disease Rating Scale (UPDRS) scores in 108 Parkinson's disease patients. Multiple regressions were conducted to examine the UPDRS subscores' unique contributions to cognitive function. When including bradykinesia, rigidity, and postural\/gait instability subscores, only bradykinesia predicted Mini Mental Status Examination (MMSE), normalized \u03b2 = \u22120.57, t(104) = \u22123.31, <jats:italic>P<\/jats:italic> &lt; 0.01, and Dementia Rating Scale\u20102 (DRS\u20102), normalized \u03b2 = \u22120.45, t(104) = \u22122.55, <jats:italic>P<\/jats:italic> &lt; 0.05. Tremor was not included in the regression analyses because it did not correlate with cognitive function. When including axial and appendicular subscores, only the axial subscore predicted MMSE, normalized \u03b2 = \u22120.39, t(105) = \u22123.19, <jats:italic>P<\/jats:italic> &lt; 0.01, and DRS\u20102 scores, normalized \u03b2 = \u22120.40, t(106) = \u22123.28, <jats:italic>P<\/jats:italic> &lt; 0.01. When including left\u2010sided and right\u2010sided subscores, only the right\u2010sided symptoms predicted DRS\u20102 scores, normalized \u03b2 = \u22120.28, t(105) = \u22122.45, <jats:italic>P<\/jats:italic> &lt; 0.05, and showed a trend toward predicting MMSE scores, normalized \u03b2 = \u22120.22, t(105) = \u22121.95, <jats:italic>P<\/jats:italic> = 0.054. We therefore found that right\u2010sided symptoms (for laterality), axial symptoms (for region), and bradykinesia (for type of symptoms) were thebest predictors of cognitive function. \u00a9 2006 Movement Disorder Society<\/jats:p>","DOI":"10.1002\/mds.21220","type":"journal-article","created":{"date-parts":[[2006,11,6]],"date-time":"2006-11-06T13:17:13Z","timestamp":1162819033000},"page":"141-144","source":"Crossref","is-referenced-by-count":50,"title":["Laterality, region, and type of motor dysfunction correlate with cognitive impairment in Parkinson's disease"],"prefix":"10.1002","volume":"22","author":[{"given":"Lindsy N.","family":"Williams","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paul","family":"Seignourel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gregory P.","family":"Crucian","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael S.","family":"Okun","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ramon L.","family":"Rodriguez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Frank M.","family":"Skidmore","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paul S.","family":"Foster","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"suffix":"IV","given":"Charles E.","family":"Jacobson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Janet","family":"Romrell","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dawn","family":"Bowers","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hubert H.","family":"Fernandez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2007,1,22]]},"reference":[{"key":"e_1_2_5_2_2","first-page":"109","volume-title":"Handbook of Parkinson's Disease","author":"Dewey RB","year":"2003"},{"key":"e_1_2_5_3_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1472-8206.2005.00317.x"},{"key":"e_1_2_5_4_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00415-004-0483-3"},{"key":"e_1_2_5_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.phrs.2004.05.005"},{"key":"e_1_2_5_6_2","doi-asserted-by":"publisher","DOI":"10.1002\/mds.20216"},{"key":"e_1_2_5_7_2","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.60.3.387"},{"key":"e_1_2_5_8_2","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.61.12.1906"},{"key":"e_1_2_5_9_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.55.4.539"},{"key":"e_1_2_5_10_2","volume-title":"Dementia Rating Scale\u20102","author":"Mattis S","year":"2002"},{"key":"e_1_2_5_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/0022-3956(75)90026-6"},{"key":"e_1_2_5_12_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF02294183"},{"key":"e_1_2_5_13_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.54.8.1596"},{"key":"e_1_2_5_14_2","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.1988.00520280079019"},{"key":"e_1_2_5_15_2","doi-asserted-by":"publisher","DOI":"10.1076\/jcen.20.3.320.820"},{"key":"e_1_2_5_16_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF02259658"},{"key":"e_1_2_5_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0010-9452(89)80059-0"}],"container-title":["Movement Disorders"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fmds.21220","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/movementdisorders.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/mds.21220","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T13:58:36Z","timestamp":1760968716000},"score":1,"resource":{"primary":{"URL":"https:\/\/movementdisorders.onlinelibrary.wiley.com\/doi\/10.1002\/mds.21220"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,1]]},"references-count":16,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2007,1]]}},"alternative-id":["10.1002\/mds.21220"],"URL":"https:\/\/doi.org\/10.1002\/mds.21220","archive":["Portico"],"relation":{},"ISSN":["0885-3185","1531-8257"],"issn-type":[{"value":"0885-3185","type":"print"},{"value":"1531-8257","type":"electronic"}],"subject":[],"published":{"date-parts":[[2007,1]]}}}