{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T19:32:27Z","timestamp":1780515147455,"version":"3.54.1"},"reference-count":14,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2007,1,26]],"date-time":"2007-01-26T00:00:00Z","timestamp":1169769600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Movement Disorders"],"published-print":{"date-parts":[[2007,3,15]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Autosomal\u2010recessive early\u2010onset Parkinsonism (AREP) due to <jats:italic>PINK1<\/jats:italic> mutations is characterized by an early\u2010onset, slowly progressive disease, with a good response to levodopa. Psychiatric and cognitive disturbances associated with AREP have rarely been reported in the literature. We describe 2 brothers from a Jewish\u2013Iraqi consanguineous family with a homozygous <jats:italic>PINK1<\/jats:italic> nonsense mutation. Both patients presented with anxiety and dysphoria accompanied by a gait disturbance that developed subsequently into a clinical depression. During the course of the disease, both developed drug\u2010induced behavioral disturbances of the hedonistic homeostatic dysregulation type and 1 had drug\u2010induced psychosis. The first patient had been diagnosed with mild mental retardation and during the 22 years of disease had further deteriorated; the second developed frontal\u2010type dementia at an early age, 20 years after onset. Their father had a psychiatric disorder but no Parkinsonism. This report expands the phenotypic profile of <jats:italic>PINK1<\/jats:italic>\u2010related disease, presenting unique psychiatric and cognitive features as part of the clinical picture. \u00a9 2007 Movement Disorder Society<\/jats:p>","DOI":"10.1002\/mds.21319","type":"journal-article","created":{"date-parts":[[2007,1,26]],"date-time":"2007-01-26T15:09:17Z","timestamp":1169824157000},"page":"566-569","source":"Crossref","is-referenced-by-count":59,"title":["Neuropsychiatric and cognitive features in autosomal\u2010recessive early parkinsonism due to PINK1 mutations"],"prefix":"10.1002","volume":"22","author":[{"given":"Lilach","family":"Ephraty","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Omer","family":"Porat","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Israeli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oren S.","family":"Cohen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olga","family":"Tunkel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shinar","family":"Yael","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasaku","family":"Hatano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nobutaka","family":"Hattori","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sharon","family":"Hassin\u2010Baer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2007,3,27]]},"reference":[{"key":"e_1_2_5_2_2","doi-asserted-by":"publisher","DOI":"10.1212\/01.WNL.0000163999.72864.FD"},{"key":"e_1_2_5_3_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11910-005-0064-6"},{"key":"e_1_2_5_4_2","first-page":"175","article-title":"Genetics of Parkinson's disease","volume":"96","author":"Bonifati V","year":"2005","journal-title":"Minerva Med"},{"key":"e_1_2_5_5_2","doi-asserted-by":"publisher","DOI":"10.1002\/mds.20316"},{"key":"e_1_2_5_6_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM200005253422103"},{"key":"e_1_2_5_7_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1077209"},{"key":"e_1_2_5_8_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1096284"},{"key":"e_1_2_5_9_2","doi-asserted-by":"publisher","DOI":"10.1212\/01.WNL.0000142258.29304.FE"},{"key":"e_1_2_5_10_2","doi-asserted-by":"publisher","DOI":"10.1212\/01.wnl.0000167546.39375.82"},{"key":"e_1_2_5_11_2","doi-asserted-by":"publisher","DOI":"10.1002\/ana.20256"},{"key":"e_1_2_5_12_2","doi-asserted-by":"publisher","DOI":"10.1212\/01.WNL.0000142089.38301.8E"},{"key":"e_1_2_5_13_2","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awl005"},{"key":"e_1_2_5_14_2","doi-asserted-by":"publisher","DOI":"10.1002\/mds.20288"},{"key":"e_1_2_5_15_2","doi-asserted-by":"publisher","DOI":"10.1212\/01.WNL.0000164009.36740.4E"}],"container-title":["Movement Disorders"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fmds.21319","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/movementdisorders.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/mds.21319","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T14:02:25Z","timestamp":1760968945000},"score":1,"resource":{"primary":{"URL":"https:\/\/movementdisorders.onlinelibrary.wiley.com\/doi\/10.1002\/mds.21319"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,3,15]]},"references-count":14,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2007,3,15]]}},"alternative-id":["10.1002\/mds.21319"],"URL":"https:\/\/doi.org\/10.1002\/mds.21319","archive":["Portico"],"relation":{},"ISSN":["0885-3185","1531-8257"],"issn-type":[{"value":"0885-3185","type":"print"},{"value":"1531-8257","type":"electronic"}],"subject":[],"published":{"date-parts":[[2007,3,15]]}}}