{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T13:52:49Z","timestamp":1790949169051,"version":"4.1.0"},"reference-count":24,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2007,3,13]],"date-time":"2007-03-13T00:00:00Z","timestamp":1173744000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Movement Disorders"],"published-print":{"date-parts":[[2007,4,30]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Recent studies support the idea of olfactory dysfunction as a very early sign of idiopathic Parkinson's disease (IPD). Aim of the present study was to clinically follow\u2010up patients with idiopathic hyposmia to find out the percentage of patients developing IPD after 4 years time. At baseline, olfactory tests had been combined with transcranial sonography of the substantia nigra and <jats:sup>123<\/jats:sup>I\u2010FP\u2010CIT SPECT imaging. At the present neurological examination, 7% of the individuals with idiopathic hyposmia had developed clinical IPD. Altogether, 13% presented with abnormalities of the motor system. Our data suggest that a combination of olfactory testing and other tests may constitute a screening tool for the risk to develop IPD. \u00a9 2007 Movement Disorder Society<\/jats:p>","DOI":"10.1002\/mds.21413","type":"journal-article","created":{"date-parts":[[2007,3,13]],"date-time":"2007-03-13T16:17:53Z","timestamp":1173802673000},"page":"839-842","source":"Crossref","is-referenced-by-count":285,"title":["Olfactory loss may be a first sign of idiopathic Parkinson's disease"],"prefix":"10.1002","volume":"22","author":[{"given":"Antje","family":"Haehner","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Hummel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cornelia","family":"Hummel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ulrike","family":"Sommer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susann","family":"Junghanns","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heinz","family":"Reichmann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2007,4,24]]},"reference":[{"key":"e_1_2_5_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/0021-9681(75)90058-2"},{"key":"e_1_2_5_3_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.33.7.943"},{"key":"e_1_2_5_4_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.38.8.1237"},{"key":"e_1_2_5_5_2","first-page":"275","volume-title":"New developments in event\u2010related potentials","author":"Hummel T","year":"1993"},{"key":"e_1_2_5_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/0140-6736(93)93027-X"},{"key":"e_1_2_5_7_2","doi-asserted-by":"publisher","DOI":"10.1093\/qjmed\/92.8.473"},{"key":"e_1_2_5_8_2","doi-asserted-by":"publisher","DOI":"10.1002\/ana.1049"},{"key":"e_1_2_5_9_2","doi-asserted-by":"publisher","DOI":"10.1002\/ana.20160"},{"key":"e_1_2_5_10_2","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awh322"},{"key":"e_1_2_5_11_2","doi-asserted-by":"publisher","DOI":"10.1002\/mds.20389"},{"key":"e_1_2_5_12_2","doi-asserted-by":"publisher","DOI":"10.1002\/mds.20141"},{"key":"e_1_2_5_13_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.45.1.182"},{"key":"e_1_2_5_14_2","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.59.6.999"},{"key":"e_1_2_5_15_2","doi-asserted-by":"publisher","DOI":"10.1007\/s007020200015"},{"key":"e_1_2_5_16_2","doi-asserted-by":"publisher","DOI":"10.1093\/chemse\/22.1.39"},{"key":"e_1_2_5_17_2","doi-asserted-by":"publisher","DOI":"10.1007\/s004050050223"},{"key":"e_1_2_5_18_2","doi-asserted-by":"publisher","DOI":"10.1002\/mds.10248"},{"key":"e_1_2_5_19_2","article-title":"Clinical significance of results from olfactory testing","author":"Gudziol V","journal-title":"Laryngoscope"},{"key":"e_1_2_5_20_2","volume-title":"Therapie des Morbus Parkinson","author":"M\u00fcller T","year":"2006"},{"issue":"11","key":"e_1_2_5_21_2","first-page":"S21","article-title":"Prevalence of Parkinson's disease in Europe: a collaborative study of population\u2010based cohorts","volume":"54","author":"de Rijk MC","year":"2000","journal-title":"Neurology"},{"key":"e_1_2_5_22_2","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.64.3.314"},{"key":"e_1_2_5_23_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.46.1.231"},{"key":"e_1_2_5_24_2","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.54.2.159"},{"key":"e_1_2_5_25_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0197-4580(02)00065-9"}],"container-title":["Movement Disorders"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fmds.21413","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/movementdisorders.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/mds.21413","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T13:47:24Z","timestamp":1760968044000},"score":1,"resource":{"primary":{"URL":"https:\/\/movementdisorders.onlinelibrary.wiley.com\/doi\/10.1002\/mds.21413"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,4,24]]},"references-count":24,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2007,4,30]]}},"alternative-id":["10.1002\/mds.21413"],"URL":"https:\/\/doi.org\/10.1002\/mds.21413","archive":["Portico"],"relation":{},"ISSN":["0885-3185","1531-8257"],"issn-type":[{"value":"0885-3185","type":"print"},{"value":"1531-8257","type":"electronic"}],"subject":[],"published":{"date-parts":[[2007,4,24]]}}}