{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T00:32:40Z","timestamp":1761006760612,"version":"build-2065373602"},"reference-count":13,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2007,3,13]],"date-time":"2007-03-13T00:00:00Z","timestamp":1173744000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Movement Disorders"],"published-print":{"date-parts":[[2007,5,15]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>We report a patient with an autosomal dominant chronic progressive external ophthalmoplegia phenotype associated with multiple mtDNA deletions in muscle from a family in which linkage analysis excluded mutations in DNA polymerase \u03b3 (POLG), adenine nucleotide translocase (ANT\u20101) or C10orf2 (Twinkle). She presented with prominent Parkinsonism characterized by prolonged benefit from levodopa (<jats:sc>L<\/jats:sc>\u2010dopa) and the later development of <jats:sc>L<\/jats:sc>\u2010dopa induced dyskinesias and motor fluctuations. Thus <jats:sc>L<\/jats:sc>\u2010dopa responsiveness, <jats:sc>L<\/jats:sc>\u2010dopa induced dyskinesias and motor fluctuations may also occur in atypical Parkinsonism of mitochondrial disease, just as they may in multiple system atrophy. \u00a9 2007 Movement Disorder Society<\/jats:p>","DOI":"10.1002\/mds.21416","type":"journal-article","created":{"date-parts":[[2007,3,13]],"date-time":"2007-03-13T16:16:24Z","timestamp":1173802584000},"page":"1020-1023","source":"Crossref","is-referenced-by-count":10,"title":["Levodopa response in Parkinsonism with multiple mitochondrial DNA deletions"],"prefix":"10.1002","volume":"22","author":[{"given":"Robert A.","family":"Wilcox","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrew","family":"Churchyard","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Henrik H.","family":"Dahl","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wendy M.","family":"Hutchison","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Denise M.","family":"Kirby","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dominic","family":"Thyagarajan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2007,3,13]]},"reference":[{"doi-asserted-by":"publisher","key":"e_1_2_6_2_2","DOI":"10.1056\/NEJMra022567"},{"doi-asserted-by":"publisher","key":"e_1_2_6_3_2","DOI":"10.1016\/j.gene.2005.03.025"},{"key":"e_1_2_6_4_2","first-page":"1743","volume-title":"Neurological therapeutics principles and practice","author":"Thyagarajan D","year":"2006"},{"doi-asserted-by":"publisher","key":"e_1_2_6_5_2","DOI":"10.1136\/jnnp.74.9.1188"},{"doi-asserted-by":"publisher","key":"e_1_2_6_6_2","DOI":"10.1002\/1531-8249(200011)48:5<730::AID-ANA6>3.0.CO;2-0"},{"doi-asserted-by":"publisher","key":"e_1_2_6_7_2","DOI":"10.1002\/1531-8249(200011)48:5<774::AID-ANA11>3.0.CO;2-I"},{"doi-asserted-by":"publisher","key":"e_1_2_6_8_2","DOI":"10.1016\/S0022-510X(96)00032-9"},{"doi-asserted-by":"publisher","key":"e_1_2_6_9_2","DOI":"10.1038\/nrn1868"},{"doi-asserted-by":"publisher","key":"e_1_2_6_10_2","DOI":"10.1038\/ng1769"},{"doi-asserted-by":"publisher","key":"e_1_2_6_11_2","DOI":"10.1038\/ng1778"},{"doi-asserted-by":"publisher","key":"e_1_2_6_12_2","DOI":"10.1212\/WNL.52.6.1255"},{"doi-asserted-by":"publisher","key":"e_1_2_6_13_2","DOI":"10.1016\/S0022-510X(02)00190-9"},{"doi-asserted-by":"publisher","key":"e_1_2_6_14_2","DOI":"10.1002\/mds.10190"}],"container-title":["Movement Disorders"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fmds.21416","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/movementdisorders.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/mds.21416","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T10:06:55Z","timestamp":1760954815000},"score":1,"resource":{"primary":{"URL":"https:\/\/movementdisorders.onlinelibrary.wiley.com\/doi\/10.1002\/mds.21416"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,3,13]]},"references-count":13,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2007,5,15]]}},"alternative-id":["10.1002\/mds.21416"],"URL":"https:\/\/doi.org\/10.1002\/mds.21416","archive":["Portico"],"relation":{},"ISSN":["0885-3185","1531-8257"],"issn-type":[{"type":"print","value":"0885-3185"},{"type":"electronic","value":"1531-8257"}],"subject":[],"published":{"date-parts":[[2007,3,13]]}}}