{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,26]],"date-time":"2025-10-26T14:11:47Z","timestamp":1761487907899,"version":"build-2065373602"},"reference-count":18,"publisher":"Wiley","issue":"13","license":[{"start":{"date-parts":[[2007,8,23]],"date-time":"2007-08-23T00:00:00Z","timestamp":1187827200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"High Q Foundation"},{"DOI":"10.13039\/501100004359","name":"Swedish Research Council","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100004359","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100006686","name":"Segerfalk Foundation","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100006686","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100006656","name":"Rosenberg Foundation","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100006656","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Lars Hierta Foundation"},{"DOI":"10.13039\/501100006285","name":"Magnus Bergvall Foundation","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100006285","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Swedish Association of Neurologically Disabled"},{"name":"Swedish Foundations of the National Board of Health and Welfare"},{"name":"Tore Nilssons Foundation"},{"name":"province of Sk\u00e5ne state grants"},{"DOI":"10.13039\/501100003792","name":"Swedish Brain Foundation","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100003792","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Movement Disorders"],"published-print":{"date-parts":[[2007,10,15]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Weight loss and anxiety frequently occur in individuals with Huntington's disease (HD) but the underlying mechanisms are not well\u2010understood. Peptides produced in the hypothalamus are involved in regulating energy homeostasis and emotion. Recent data suggest that changes in neuropeptide levels may be reflected in the cerebrospinal fluid (CSF), and could therefore serve as biomarkers for HD. Cocaine\u2010 and amphetamine\u2010regulated transcript (CART) is a neuropetide expressed in several brain regions such as the hypothalamus, amygdala, and hippocampus. CART has been shown to increase anxiety and reduce food intake in rodents by as yet unknown mechanisms. Individuals with a <jats:italic>CART<\/jats:italic> mutation exhibit increased anxiety. In cross\u2010sectional CSF samples from HD patients (n = 39), we found that levels of CART peptide were significantly increased by 23% compared to control subjects (n = 28). Increased CART levels in HD therefore hold promise as a biomarker as well as a potential pathogenic mediator of symptoms. \u00a9 2007 Movement Disorder Society<\/jats:p>","DOI":"10.1002\/mds.21447","type":"journal-article","created":{"date-parts":[[2007,8,24]],"date-time":"2007-08-24T21:19:44Z","timestamp":1187990384000},"page":"1952-1954","source":"Crossref","is-referenced-by-count":18,"title":["Cocaine\u2010 and amphetamine\u2010regulated transcript is increased in Huntington disease"],"prefix":"10.1002","volume":"22","author":[{"given":"Maria","family":"Bj\u00f6rkqvist","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Blair R.","family":"Leavitt","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J\u00f6rgen E.","family":"Nielsen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bernhard","family":"Landwehrmeyer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniel","family":"Ecker","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hindrik","family":"Mulder","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Patrik","family":"Brundin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"\u00c5sa","family":"Peters\u00e9n","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2007,10,26]]},"reference":[{"key":"e_1_2_6_2_2","first-page":"213","article-title":"Topography of cerebral atrophy in early Huntington's disease: a voxel based morphometric MRI study","volume":"75","author":"Kassubek J","year":"2004","journal-title":"J Neurol Neurosurg Psychiatry"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1097\/00005072-199007000-00002"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/0304-3940(91)90443-W"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddi004"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(93)90585-E"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.wco.0000186842.51129.cb"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1460-9568.2006.04985.x"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-1331.2006.01319.x"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.mp.4001638"},{"key":"e_1_2_6_11_2","doi-asserted-by":"publisher","DOI":"10.1054\/npep.2002.0887"},{"key":"e_1_2_6_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.peptides.2006.01.027"},{"key":"e_1_2_6_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.peptides.2005.11.027"},{"key":"e_1_2_6_14_2","doi-asserted-by":"publisher","DOI":"10.1124\/jpet.105.091512"},{"key":"e_1_2_6_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.peptides.2006.01.026"},{"key":"e_1_2_6_16_2","doi-asserted-by":"publisher","DOI":"10.1002\/da.20156"},{"key":"e_1_2_6_17_2","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/50.1.145"},{"key":"e_1_2_6_18_2","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.1320210213"},{"key":"e_1_2_6_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.nut.2003.10.007"}],"container-title":["Movement Disorders"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fmds.21447","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fmds.21447","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/movementdisorders.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/mds.21447","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T13:49:19Z","timestamp":1760968159000},"score":1,"resource":{"primary":{"URL":"https:\/\/movementdisorders.onlinelibrary.wiley.com\/doi\/10.1002\/mds.21447"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,10,15]]},"references-count":18,"journal-issue":{"issue":"13","published-print":{"date-parts":[[2007,10,15]]}},"alternative-id":["10.1002\/mds.21447"],"URL":"https:\/\/doi.org\/10.1002\/mds.21447","archive":["Portico"],"relation":{},"ISSN":["0885-3185","1531-8257"],"issn-type":[{"type":"print","value":"0885-3185"},{"type":"electronic","value":"1531-8257"}],"subject":[],"published":{"date-parts":[[2007,10,15]]}}}