{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T16:21:24Z","timestamp":1790871684138,"version":"4.1.0"},"reference-count":41,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2007,5,7]],"date-time":"2007-05-07T00:00:00Z","timestamp":1178496000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Movement Disorders"],"published-print":{"date-parts":[[2007,7,15]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>There is substantial evidence to support a role for small vessel disease (SVD) as a cause for vascular parkinsonism (VP). Using [<jats:sup>123<\/jats:sup>I] FP\u2010CIT SPECT (single photon emission computed tomography), we have tried to determine whether VP patients have pre\u2010synaptic dopaminergic function similar to PD patients, and whether the severity of parkinsonian symptoms as well as the levodopa response in VP patients are correlated with pre\u2010synaptic dopaminergic dysfunction. Thirteen patients fulfilling operational clinical criteria for VP had [<jats:sup>123<\/jats:sup>I] FP\u2010CIT scans. Mean [<jats:sup>123<\/jats:sup>I] FP\u2010CIT uptake in the basal ganglia was significantly lower in VP patients than in healthy controls, and the asymmetry index was not significantly different between these groups. In contrast, compared with the PD group, only the mean asymmetry index was significantly lower in VP patients. None of the parameters measured was significantly different between VP patients who had an insidious onset of parkinsonism (VPi) and those who had an acute onset (VPa). There was a significant correlation between the bilateral basal ganglia FP\u2010CIT uptake reduction in the VP patients and UPDRS motor scores, but not with the mean % reduction in motor UPDRS after levodopa. We suggest that in the majority of VP patients, pre\u2010synaptic dopaminergic function is reduced. The presence of a rather symmetrical FP\u2010CIT uptake in the basal ganglia may help to distinguish VP from PD and could therefore be used as a criterion for the clinical diagnosis of VP. \u00a9 2007 Movement Disorder Society<\/jats:p>","DOI":"10.1002\/mds.21479","type":"journal-article","created":{"date-parts":[[2007,5,7]],"date-time":"2007-05-07T17:16:45Z","timestamp":1178558205000},"page":"1278-1285","source":"Crossref","is-referenced-by-count":93,"title":["[<sup>123<\/sup>I] FP\u2010CIT spect study in vascular parkinsonism and Parkinson's disease"],"prefix":"10.1002","volume":"22","author":[{"given":"Jan","family":"Zijlmans","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew","family":"Evans","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Flavia","family":"Fontes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Regina","family":"Katzenschlager","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Svetoslav","family":"Gacinovic","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew J","family":"Lees","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Durval","family":"Costa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2007,5,7]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.34.11.1516"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.49.9.1087"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1002\/mds.870020101"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1002\/mds.870040306"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.45.12.2183"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1002\/mds.20083"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0959-4388(96)80024-9"},{"key":"e_1_2_6_9_2","first-page":"1879","article-title":"Imaging of dopamine transporters with iodine\u2010123\u2010FP\u2010CIT SPECT in healthy controls and patients with Parkinson's disease","volume":"39","author":"Booij J","year":"1998","journal-title":"J Nucl Med"},{"key":"e_1_2_6_10_2","first-page":"1500","article-title":"Iodine\u2010123\u2010beta\u2010CIT and iodine\u2010123\u2010FPCIT SPECT measurement of dopamine transporters in healthy subjects and Parkinson's patients","volume":"39","author":"Seibyl JP","year":"1998","journal-title":"J Nucl Med"},{"key":"e_1_2_6_11_2","doi-asserted-by":"publisher","DOI":"10.1002\/1531-8257(200007)15:4<692::AID-MDS1014>3.0.CO;2-V"},{"key":"e_1_2_6_12_2","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.62.2.133"},{"key":"e_1_2_6_13_2","doi-asserted-by":"publisher","DOI":"10.1002\/ana.10475"},{"key":"e_1_2_6_14_2","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.55.3.181"},{"key":"e_1_2_6_15_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0404.2007.00818.x"},{"key":"e_1_2_6_16_2","doi-asserted-by":"publisher","DOI":"10.1109\/TNS.1978.4329385"},{"key":"e_1_2_6_17_2","first-page":"189","article-title":"\u201cMini\u2010mental state\u201d. 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