{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T14:49:28Z","timestamp":1786978168999,"version":"build-2736575974"},"reference-count":21,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2007,4,27]],"date-time":"2007-04-27T00:00:00Z","timestamp":1177632000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Movement Disorders"],"published-print":{"date-parts":[[2007,7,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>We aimed to obtain a reliable, objective scale representing disease severity for appropriate management of patients with Parkinson's disease (PD). Nineteen patients with PD at the Department of Neurology, Tokyo University Hospital, were classified into mild (n = 10) or severe groups (n = 9) depending on their Hoehn\u2010Yahr scores, and wore accelerometers on their wrists for more than 6 consecutive days. During this time we monitored their subjective assessments of symptom severity and analyzed the power\u2010law exponents (\u03b1) for local maxima and minima of fluctuations in the activity time series. Statistical comparisons were made between the severe and mild groups and of individual patients on \u201cgood condition\u201d and \u201cbad condition\u201d days, as well as between days before and after antiparkinsonism medication. In all patients, the \u03b1 for local maxima was always lower when parkinsonism was mild than when severe. Presence of tremor did not influence the \u03b1 for local maxima. As the lower \u03b1 value for local maxima of fluctuations in activity records reflects more frequent switching behavior from low to high physical activities or the severity of akinesia, actigraph monitoring of parkinsonism, and analysis of its power\u2010law correlation may provide useful objective information for controlling parkinsonism in outpatient clinics and for evaluating new antiparkinsonism drugs. \u00a9 2007 Movement Disorder Society<\/jats:p>","DOI":"10.1002\/mds.21527","type":"journal-article","created":{"date-parts":[[2007,4,27]],"date-time":"2007-04-27T17:48:19Z","timestamp":1177696099000},"page":"1308-1313","source":"Crossref","is-referenced-by-count":20,"title":["Power\u2010law temporal autocorrelation of activity reflects severity of parkinsonism"],"prefix":"10.1002","volume":"22","author":[{"given":"Weidong","family":"Pan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kyoko","family":"Ohashi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshiharu","family":"Yamamoto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shin","family":"Kwak","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2007,4,27]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1002\/mds.870090112"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1159\/000058048"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1081\/CBI-120027980"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/0006-3223(95)00370-3"},{"key":"e_1_2_6_6_2","first-page":"18","article-title":"Rest\u2010activity and body\u2010temperature rhythm disorders in elderly patients with dementia\u2014senile dementia of Alzheimer's type and multi\u2010infarct dementia","volume":"35","author":"Okawa M","year":"1995","journal-title":"Rinsho Shinkeigaku"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.3109\/10673229509017161"},{"key":"e_1_2_6_8_2","first-page":"3038","article-title":"Marked 24\u2010h rest\/activity rhythms are associated with better quality of life, better response, and longer survival in patients with metastatic colorectal cancer and good performance status","volume":"6","author":"Mormont MC","year":"2000","journal-title":"Clin Cancer Res"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1002\/mds.10381"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/0022-510X(93)90148-R"},{"key":"e_1_2_6_11_2","doi-asserted-by":"publisher","DOI":"10.1109\/10.661163"},{"key":"e_1_2_6_12_2","doi-asserted-by":"publisher","DOI":"10.1002\/mds.20900"},{"key":"e_1_2_6_13_2","doi-asserted-by":"publisher","DOI":"10.1103\/PhysRevE.68.065204"},{"key":"e_1_2_6_14_2","doi-asserted-by":"publisher","DOI":"10.1063\/1.166141"},{"key":"e_1_2_6_15_2","doi-asserted-by":"publisher","DOI":"10.1088\/1741-2560\/1\/1\/002"},{"key":"e_1_2_6_16_2","doi-asserted-by":"publisher","DOI":"10.1109\/TBME.2005.859801"},{"key":"e_1_2_6_17_2","doi-asserted-by":"publisher","DOI":"10.1103\/PhysRevE.70.050901"},{"key":"e_1_2_6_18_2","doi-asserted-by":"publisher","DOI":"10.1038\/20924"},{"key":"e_1_2_6_19_2","doi-asserted-by":"publisher","DOI":"10.1081\/CBI-120002606"},{"key":"e_1_2_6_20_2","first-page":"115","article-title":"Circadian locomotor activity rhythms in Alzheimer's disease","volume":"5","author":"Satlin A","year":"1991","journal-title":"Neuropsychopharmacology"},{"key":"e_1_2_6_21_2","doi-asserted-by":"publisher","DOI":"10.1002\/ana.20574"},{"key":"e_1_2_6_22_2","doi-asserted-by":"publisher","DOI":"10.1016\/0165-0270(95)00146-8"}],"container-title":["Movement Disorders"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fmds.21527","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/movementdisorders.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/mds.21527","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T12:24:05Z","timestamp":1760963045000},"score":1,"resource":{"primary":{"URL":"https:\/\/movementdisorders.onlinelibrary.wiley.com\/doi\/10.1002\/mds.21527"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,4,27]]},"references-count":21,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2007,7,15]]}},"alternative-id":["10.1002\/mds.21527"],"URL":"https:\/\/doi.org\/10.1002\/mds.21527","archive":["Portico"],"relation":{},"ISSN":["0885-3185","1531-8257"],"issn-type":[{"value":"0885-3185","type":"print"},{"value":"1531-8257","type":"electronic"}],"subject":[],"published":{"date-parts":[[2007,4,27]]}}}