{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T06:27:10Z","timestamp":1789540030338,"version":"build-2803163510"},"reference-count":40,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2007,5,21]],"date-time":"2007-05-21T00:00:00Z","timestamp":1179705600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Movement Disorders"],"published-print":{"date-parts":[[2007,8,15]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Essential tremor (ET) is a late\u2010life neurological disease. Mild cognitive deficits as well as an association with prevalent dementia have been reported in recent case\u2013control studies. We determined whether ET was associated with an increased risk of incident dementia. In a population\u2010based study of older people in central Spain (NEDICES), nondemented ET cases and controls were followed prospectively. Incident dementia at follow\u2010up was diagnosed using DSM\u2010IV criteria and the risk of incident dementia was estimated in ET cases versus controls using Cox proportional hazards models. 3,891 participants had a mean duration of follow\u2010up of 3.2 years. Sixteen (7.8%) of 206 ET cases developed incident dementia versus 145 (3.9%) of 3,685 controls (unadjusted relative risk [RR] = 2.08, 95% CI = 1.24\u20133.50, <jats:italic>P<\/jats:italic> = 0.006 and adjusted RR = 1.66, 95% CI = 0.99\u20132.80, <jats:italic>P<\/jats:italic> = 0.054). In an adjusted model, ET cases with tremor onset after age 65 years were twice as likely to develop incident dementia than were controls (RR = 1.98, 95% CI = 1.14\u20133.45, <jats:italic>P<\/jats:italic> = 0.01), whereas ET cases with tremor onset &lt; age 65 years and controls were equally to develop incident dementia (RR = 0.74, 95% CI = 0.19\u20133.20, <jats:italic>P<\/jats:italic> = 0.79). Although ET is often considered a benign condition, in this prospective, population\u2010based study, elderly\u2010onset ET was associated with an increased risk of incident dementia. The basis for this dementia, which is not known, requires additional study. \u00a9 2007 Movement Disorder Society<\/jats:p>","DOI":"10.1002\/mds.21553","type":"journal-article","created":{"date-parts":[[2007,5,21]],"date-time":"2007-05-21T18:44:51Z","timestamp":1179773091000},"page":"1573-1580","source":"Crossref","is-referenced-by-count":184,"title":["Risk of incident dementia in essential tremor: A population\u2010based study"],"prefix":"10.1002","volume":"22","author":[{"given":"F\u00e9lix","family":"Bermejo\u2010Pareja","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elan D.","family":"Louis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juli\u00e1n","family":"Benito\u2010Le\u00f3n","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2007,5,21]]},"reference":[{"key":"e_1_2_7_2_2","doi-asserted-by":"publisher","DOI":"10.1212\/01.WNL.0000099075.19951.8C"},{"key":"e_1_2_7_3_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.57.8.1389"},{"key":"e_1_2_7_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(05)00991-9"},{"key":"e_1_2_7_5_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1468-1331.2002.00341.x"},{"key":"e_1_2_7_6_2","doi-asserted-by":"publisher","DOI":"10.1212\/01.wnl.0000192393.05850.ec"},{"key":"e_1_2_7_7_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.57.5.785"},{"key":"e_1_2_7_8_2","doi-asserted-by":"publisher","DOI":"10.1007\/s004150170181"},{"key":"e_1_2_7_9_2","doi-asserted-by":"publisher","DOI":"10.1017\/S1355617702001121"},{"key":"e_1_2_7_10_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.58.11.1706"},{"key":"e_1_2_7_11_2","first-page":"S30","article-title":"Cognition and affect in idiopathic essential tremor","volume":"16","author":"Vermilion K","year":"2001","journal-title":"Mov Disord"},{"key":"e_1_2_7_12_2","doi-asserted-by":"publisher","DOI":"10.1212\/01.wnl.0000216134.88617.de"},{"key":"e_1_2_7_13_2","doi-asserted-by":"publisher","DOI":"10.1002\/mds.10376"},{"key":"e_1_2_7_14_2","doi-asserted-by":"publisher","DOI":"10.1212\/01.WNL.0000113727.73153.68"},{"key":"e_1_2_7_15_2","doi-asserted-by":"publisher","DOI":"10.1212\/01.WNL.0000161852.70374.01"},{"key":"e_1_2_7_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.puhe.2003.10.007"},{"key":"e_1_2_7_17_2","doi-asserted-by":"publisher","DOI":"10.1159\/000054794"},{"key":"e_1_2_7_18_2","first-page":"464","article-title":"The Italian Longitudinal Study on Aging (ILSA): design and methods","volume":"6","author":"Maggi S","year":"1994","journal-title":"Aging (Milano)"},{"key":"e_1_2_7_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/0022-3956(75)90026-6"},{"key":"e_1_2_7_20_2","doi-asserted-by":"publisher","DOI":"10.1093\/geronj\/37.3.323"},{"key":"e_1_2_7_21_2","volume-title":"Cien escalas de inter\u00e9s en Neurolog\u00eda Cl\u00ednica","author":"Bermejo\u2010Pareja F","year":"2001"},{"issue":"2","key":"e_1_2_7_22_2","first-page":"A365","article-title":"Cognitive versus functional screening for dementia across different countries: cross\u2010cultural validation of the Mini\u2010Mental State Examination (MMSE) and the Pfeffer activities questionnaire (PFAQ) against the standardised clinical diagnosis of dementia","volume":"44","author":"Baldereschi M","year":"1994","journal-title":"Neurology"},{"key":"e_1_2_7_23_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.44.2.239"},{"key":"e_1_2_7_24_2","series-title":"Recent developments in Parkinson's disease","first-page":"153","author":"Fahn S","year":"1987"},{"key":"e_1_2_7_25_2","first-page":"99","article-title":"Versi\u00f3n reducida del test Barcelona (I): subtest y perfiles de normalidad","volume":"12","author":"Pe\u00f1a\u2010Casanova J","year":"1997","journal-title":"Neurolog\u00eda"},{"key":"e_1_2_7_26_2","first-page":"401","article-title":"Registro Multicentrico de casos incidentes de demencia","volume":"9","author":"Bermejo F","year":"1994","journal-title":"Neurolog\u00eda"},{"key":"e_1_2_7_27_2","doi-asserted-by":"publisher","DOI":"10.2466\/pms.1985.61.3f.1283"},{"key":"e_1_2_7_28_2","doi-asserted-by":"publisher","DOI":"10.1080\/01688638008403788"},{"key":"e_1_2_7_29_2","volume-title":"Wechsler Memory Scale\u2010Revised","author":"Wechsler D","year":"1987"},{"key":"e_1_2_7_30_2","doi-asserted-by":"publisher","DOI":"10.1006\/brcg.1997.0877"},{"key":"e_1_2_7_31_2","volume-title":"DSM\u2010IV. 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