{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T11:47:31Z","timestamp":1791028051276,"version":"4.1.0"},"reference-count":29,"publisher":"Wiley","issue":"13","license":[{"start":{"date-parts":[[2007,7,6]],"date-time":"2007-07-06T00:00:00Z","timestamp":1183680000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Movement Disorders"],"published-print":{"date-parts":[[2007,10,15]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Idiopathic cranial\u2013cervical dystonia (ICCD) is an adult\u2010onset dystonia syndrome affecting orbicularis oculi, facial, oromandibular, and cervical musculature. ICCD is frequently difficult to treat medically. Deep brain stimulation (DBS) of the globus pallidus internus (GPi) is a highly effective treatment for idiopathic generalized dystonia, however less is known about the effect of GPi DBS on ICCD. In this article, we present the results from a pilot study assessing the effect of GPi DBS in a series of patients with ICCD. Six patients underwent bilateral stereotactic implantation of DBS leads into the sensorimotor GPi. Patients were evaluated with the Burke\u2013Fahn\u2013Marsden dystonia rating scale (BFMDRS) and Toronto western spamodic torticollis rating scale (TWSTRS) before surgery and 6 months postoperatively. At 6 months, patients showed a 72% mean improvement in the BFMDRS total movement score (<jats:italic>P<\/jats:italic> &lt; 0.028, Wilcoxin signed rank test). The mean BFMDRS disability score showed a trend toward improvement (<jats:italic>P<\/jats:italic> &lt; 0.06). The total TWSTRS score improved 54% (<jats:italic>P<\/jats:italic> &lt; 0.043). Despite improvement in dystonia, mild worsening of motor function was reported in previously nondystonic body regions with stimulation in 4 patients. Although GPi DBS was effective in these patients, the influence of GPi DBS on nondystonic body regions deserves further investigation. \u00a9 2007 Movement Disorder Society<\/jats:p>","DOI":"10.1002\/mds.21580","type":"journal-article","created":{"date-parts":[[2007,7,6]],"date-time":"2007-07-06T17:51:30Z","timestamp":1183744290000},"page":"1885-1891","source":"Crossref","is-referenced-by-count":167,"title":["Pallidal deep brain stimulation in patients with cranial\u2013cervical dystonia (Meige syndrome)"],"prefix":"10.1002","volume":"22","author":[{"given":"Jill L.","family":"Ostrem","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"suffix":"Jr.","given":"William J.","family":"Marks","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Monica M.","family":"Volz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susan 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