{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,6]],"date-time":"2026-03-06T14:30:56Z","timestamp":1772807456202,"version":"3.50.1"},"reference-count":30,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2007,6,1]],"date-time":"2007-06-01T00:00:00Z","timestamp":1180656000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Movement Disorders"],"published-print":{"date-parts":[[2007,8,15]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>We conducted a historical cohort study of 981 first\u2010degree relatives of 162 patients with Parkinson's disease (PD) and of 838 first\u2010degree relatives of 147 controls representative of the population of Olmsted County, Minnesota. In addition, we studied 2,684 first\u2010degree relatives of 411 patients with PD referred to the Mayo Clinic. Relatives were interviewed and screened for tremor either directly or through a proxy, and those who screened positive were examined or copies of their medical records were obtained to confirm the diagnosis of essential tremor (ET). We also obtained ET information from a medical records\u2010linkage system (family study method). In the population\u2010based sample, the risk of ET was significantly increased for relatives of patients with onset of PD \u2264 66 years (first tertile; hazard ratio [HR] = 2.24; 95% confidence interval [95% CI] = 1.26\u20133.98; <jats:italic>P<\/jats:italic> = 0.006). In the referral\u2010based sample, the risk of ET among relatives increased with younger onset of PD in patients (linear trend; <jats:italic>P<\/jats:italic> = 0.001), and was higher in relatives of PD patients with the tremor\u2010predominant or mixed form when compared with relatives of patients with the akinetic\u2010rigid form, and in men compared with women. These findings suggest that PD and ET may share familial susceptibility factors. \u00a9 2007 Movement Disorder Society<\/jats:p>","DOI":"10.1002\/mds.21584","type":"journal-article","created":{"date-parts":[[2007,6,1]],"date-time":"2007-06-01T15:16:42Z","timestamp":1180711002000},"page":"1607-1614","source":"Crossref","is-referenced-by-count":56,"title":["Increased risk of essential tremor in first\u2010degree relatives of patients with Parkinson's disease"],"prefix":"10.1002","volume":"22","author":[{"given":"Walter A.","family":"Rocca","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"James H.","family":"Bower","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J. Eric","family":"Ahlskog","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexis","family":"Elbaz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Brandon R.","family":"Grossardt","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shannon K.","family":"McDonnell","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniel J.","family":"Schaid","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Demetrius M.","family":"Maraganore","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2007,6]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410170404"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410240106"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.61.7.931"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.parkreldis.2006.05.033"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1212\/01.WNL.0000068007.58423.C2"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1002\/ana.20228"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1159\/000083612"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1002\/ana.20844"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.52.6.1214"},{"key":"e_1_2_6_11_2","doi-asserted-by":"publisher","DOI":"10.1002\/1531-8257(200009)15:5<819::AID-MDS1009>3.0.CO;2-P"},{"key":"e_1_2_6_12_2","doi-asserted-by":"publisher","DOI":"10.1097\/00001648-200203000-00010"},{"key":"e_1_2_6_13_2","doi-asserted-by":"publisher","DOI":"10.4065\/71.3.266"},{"key":"e_1_2_6_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0895-4356(98)00017-1"},{"key":"e_1_2_6_15_2","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.47.5.466"},{"key":"e_1_2_6_16_2","first-page":"S21","article-title":"Essential tremor: clinical characteristics","volume":"54","author":"Jankovic J","year":"2000","journal-title":"Neurology"},{"key":"e_1_2_6_17_2","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4757-3294-8"},{"key":"e_1_2_6_18_2","doi-asserted-by":"publisher","DOI":"10.1080\/01621459.1989.10478874"},{"key":"e_1_2_6_19_2","doi-asserted-by":"publisher","DOI":"10.1017\/S031716710004364X"},{"key":"e_1_2_6_20_2","first-page":"313","article-title":"Family history of tremor in Parkinson's disease compared with those of controls and patients with idiopathic dystonia","volume":"45","author":"Lang AE","year":"1986","journal-title":"Adv Neurol"},{"key":"e_1_2_6_21_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.45.4.645"},{"key":"e_1_2_6_22_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.43.6.1173"},{"key":"e_1_2_6_23_2","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410190318"},{"key":"e_1_2_6_24_2","doi-asserted-by":"publisher","DOI":"10.1017\/S0317167100044541"},{"key":"e_1_2_6_25_2","first-page":"492","volume-title":"Progress of neurogenetics","author":"Duvoisin RC","year":"1969"},{"key":"e_1_2_6_26_2","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.47.7.734"},{"key":"e_1_2_6_27_2","doi-asserted-by":"publisher","DOI":"10.1002\/mds.870130105"},{"key":"e_1_2_6_28_2","doi-asserted-by":"publisher","DOI":"10.1016\/0021-9681(79)90012-2"},{"key":"e_1_2_6_29_2","doi-asserted-by":"publisher","DOI":"10.1002\/mds.1040"},{"key":"e_1_2_6_30_2","doi-asserted-by":"publisher","DOI":"10.1002\/ana.1022"},{"key":"e_1_2_6_31_2","doi-asserted-by":"publisher","DOI":"10.1159\/000109681"}],"container-title":["Movement Disorders"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fmds.21584","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/movementdisorders.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/mds.21584","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T08:54:05Z","timestamp":1760950445000},"score":1,"resource":{"primary":{"URL":"https:\/\/movementdisorders.onlinelibrary.wiley.com\/doi\/10.1002\/mds.21584"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,6]]},"references-count":30,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2007,8,15]]}},"alternative-id":["10.1002\/mds.21584"],"URL":"https:\/\/doi.org\/10.1002\/mds.21584","archive":["Portico"],"relation":{},"ISSN":["0885-3185","1531-8257"],"issn-type":[{"value":"0885-3185","type":"print"},{"value":"1531-8257","type":"electronic"}],"subject":[],"published":{"date-parts":[[2007,6]]}}}