{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,21]],"date-time":"2026-01-21T12:22:08Z","timestamp":1768998128233,"version":"3.49.0"},"reference-count":15,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2007,6,19]],"date-time":"2007-06-19T00:00:00Z","timestamp":1182211200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Movement Disorders"],"published-print":{"date-parts":[[2007,8,15]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>We performed a pilot, double\u2010blind, placebo\u2010controlled, randomized trial to evaluate the efficacy and tolerability of pregabalin (PGB, Lyrica), an antiepileptic agent, in treating essential tremor (ET). Twenty two patients with ET were randomly assigned to receive PGB or placebo. PGB was initiated at 50 mg\/day and was escalated by 75 mg\/day every 4 days to a maximum dose of 600 mg\/day. Patients were evaluated by accelerometry and the Fahn\u2013Tolosa\u2013Marin (FTM) rating scale. There was a significant reduction in tremor amplitude in the PGB group compared with the placebo group, as measured by accelerometry, at a mean dose of 286.76 \u00b1 100.05 mg\/day. Action tremor limb scores on the FTM also improved in the PGB group compared with the placebo group (<jats:italic>P<\/jats:italic>\u2010value for multilevel modeling = 0.04). PGB was fairly well tolerated, with about one\u2010third of patients dropping out of the study because of adverse events. PGB provided significant improvements in accelerometry and in action tremor limb scores on the FTM. However, larger studies are needed to further evaluate the potential effect of PGB on ET. \u00a9 2007 Movement Disorder Society<\/jats:p>","DOI":"10.1002\/mds.21629","type":"journal-article","created":{"date-parts":[[2007,6,19]],"date-time":"2007-06-19T13:17:51Z","timestamp":1182259071000},"page":"1660-1663","source":"Crossref","is-referenced-by-count":45,"title":["A pilot, double\u2010blind, placebo\u2010controlled trial of pregabalin (Lyrica) in the treatment of essential tremor"],"prefix":"10.1002","volume":"22","author":[{"given":"Theresa A.","family":"Zesiewicz","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christopher L.","family":"Ward","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert A.","family":"Hauser","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jason L.","family":"Salemi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shaila","family":"Siraj","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria\u2010Carmen","family":"Wilson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kelly L.","family":"Sullivan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2007,6,19]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.39.12.1587"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1212\/01.WNL.0000068024.20285.65"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1002\/mds.21211"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1097\/00029679-199517060-00001"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/0022-3956(75)90026-6"},{"key":"e_1_2_6_7_2","first-page":"225","volume-title":"Parkinson's disease and movement disorders","author":"Fahn SE","year":"1988"},{"key":"e_1_2_6_8_2","first-page":"218","volume-title":"ECDEU assessment manual for psychopharmacology\u2014revised","author":"Guy W","year":"1976"},{"key":"e_1_2_6_9_2","volume-title":"Handbook of pain assessment","author":"Jensen MP","year":"1992"},{"key":"e_1_2_6_10_2","first-page":"725","article-title":"Standardization of a neuromotor test battery: the CATSYS system","volume":"21","author":"Despres C","year":"2000","journal-title":"Neurotoxicology"},{"key":"e_1_2_6_11_2","doi-asserted-by":"publisher","DOI":"10.1212\/01.wnl.0000231513.23919.a1"},{"key":"e_1_2_6_12_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI200523625"},{"key":"e_1_2_6_13_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF01273153"},{"key":"e_1_2_6_14_2","doi-asserted-by":"publisher","DOI":"10.1002\/1531-8249(199908)46:2<249::AID-ANA15>3.0.CO;2-C"},{"key":"e_1_2_6_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.tips.2006.12.006"},{"key":"e_1_2_6_16_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00585623"}],"container-title":["Movement Disorders"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fmds.21629","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/movementdisorders.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/mds.21629","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T08:54:07Z","timestamp":1760950447000},"score":1,"resource":{"primary":{"URL":"https:\/\/movementdisorders.onlinelibrary.wiley.com\/doi\/10.1002\/mds.21629"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,6,19]]},"references-count":15,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2007,8,15]]}},"alternative-id":["10.1002\/mds.21629"],"URL":"https:\/\/doi.org\/10.1002\/mds.21629","archive":["Portico"],"relation":{},"ISSN":["0885-3185","1531-8257"],"issn-type":[{"value":"0885-3185","type":"print"},{"value":"1531-8257","type":"electronic"}],"subject":[],"published":{"date-parts":[[2007,6,19]]}}}