{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T19:51:32Z","timestamp":1791143492715,"version":"4.1.0"},"reference-count":24,"publisher":"Wiley","issue":"14","license":[{"start":{"date-parts":[[2007,8,8]],"date-time":"2007-08-08T00:00:00Z","timestamp":1186531200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Movement Disorders"],"published-print":{"date-parts":[[2007,10,31]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Lateral axial dystonia (LAD) has been described in patients with Parkinson's disease (PD), but treatment might be more controversial than treatment of LAD in other neurological conditions. Our study was designed as a blinded cross\u2010over with botulinum toxin (BTX) and placebo in order to investigate the efficacy of BTX in PD LAD. Nine patients with LAD who failed to experience benefit from oral medications were randomly assigned to 2 groups, 4 patients received BTX and 5 placebo as a first treatment, and were switched\u2010over to BTX or placebo in the following treatment session, performed 3 months after the first session. Each patient was evaluated at baseline, 2 and 4 weeks after injection and after 3 months follow\u2010up with the Trunk Dystonia Disability Scale (TDDS), a Visual Analogue Scale (VAS) and a goniometric measurement of the lateral displacement. Patients were videotaped at each visit. None of the patients of the placebo group experienced benefit from treatment. BTX treatment was effective in 6 patients. One patient reported subjective benefit, with improvement of VAS score and mild improvement of TDDS score, but with no improvement of flexion degree. Two patients did not report any benefit. Four patients opted to continue to receive BTX treatment for 2 years after the cross\u2010over study. Our study shows that BTX could be considered a possible treatment for LAD in parkinsonism. \u00a9 2007 Movement Disorder Society<\/jats:p>","DOI":"10.1002\/mds.21694","type":"journal-article","created":{"date-parts":[[2007,8,8]],"date-time":"2007-08-08T18:16:22Z","timestamp":1186596982000},"page":"2097-2103","source":"Crossref","is-referenced-by-count":109,"title":["Botulinum toxin treatment of lateral axial dystonia in parkinsonism"],"prefix":"10.1002","volume":"22","author":[{"given":"Laura","family":"Bonanni","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Astrid","family":"Thomas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sara","family":"Varanese","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vincenzo","family":"Scorrano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marco","family":"Onofrj","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2007,8,8]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00316159"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/0006-3223(92)90269-6"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1002\/mds.870130330"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.2165\/00023210-200216030-00003"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1002\/mds.20164"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1212\/01.WNL.0000094201.80888.DA"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/0006-3223(88)90095-9"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1177\/089198879100400109"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.1002\/mds.870130342"},{"key":"e_1_2_6_11_2","doi-asserted-by":"publisher","DOI":"10.1002\/mds.21168"},{"key":"e_1_2_6_12_2","doi-asserted-by":"publisher","DOI":"10.1002\/mds.21154"},{"issue":"7","key":"e_1_2_6_13_2","first-page":"VII\/17","article-title":"Lateral flexion in Parkinson's disease and Pisa syndrome","volume":"253","author":"Yokochi F","year":"2006","journal-title":"J Neurol"},{"key":"e_1_2_6_14_2","doi-asserted-by":"publisher","DOI":"10.1002\/mds.870110405"},{"issue":"4","key":"e_1_2_6_15_2","doi-asserted-by":"crossref","first-page":"57S","DOI":"10.1097\/00004714-198808000-00004","article-title":"Pharmacologic studies of tardive dyskinesia","volume":"8","author":"Lieberman J","year":"1988","journal-title":"J Clin Psychopharmacol"},{"key":"e_1_2_6_16_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.38.3.391"},{"key":"e_1_2_6_17_2","doi-asserted-by":"publisher","DOI":"10.1097\/00005053-199302000-00011"},{"key":"e_1_2_6_18_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00886877"},{"key":"e_1_2_6_19_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.wnf.0000183449.04271.05"},{"key":"e_1_2_6_20_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00415-006-0320-z"},{"key":"e_1_2_6_21_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1997.03540350075038"},{"key":"e_1_2_6_22_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(00)04337-3"},{"key":"e_1_2_6_23_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-1331.2006.01438.x"},{"key":"e_1_2_6_24_2","first-page":"241","volume-title":"Quantification of neurologic deficit","author":"Fahn S","year":"1989"},{"key":"e_1_2_6_25_2","doi-asserted-by":"publisher","DOI":"10.1136\/ard.37.4.378"}],"container-title":["Movement Disorders"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fmds.21694","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/movementdisorders.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/mds.21694","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T11:54:03Z","timestamp":1760961243000},"score":1,"resource":{"primary":{"URL":"https:\/\/movementdisorders.onlinelibrary.wiley.com\/doi\/10.1002\/mds.21694"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,8,8]]},"references-count":24,"journal-issue":{"issue":"14","published-print":{"date-parts":[[2007,10,31]]}},"alternative-id":["10.1002\/mds.21694"],"URL":"https:\/\/doi.org\/10.1002\/mds.21694","archive":["Portico"],"relation":{},"ISSN":["0885-3185","1531-8257"],"issn-type":[{"value":"0885-3185","type":"print"},{"value":"1531-8257","type":"electronic"}],"subject":[],"published":{"date-parts":[[2007,8,8]]}}}