{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T18:22:32Z","timestamp":1790706152736,"version":"4.1.0"},"reference-count":30,"publisher":"Wiley","issue":"16","license":[{"start":{"date-parts":[[2007,9,25]],"date-time":"2007-09-25T00:00:00Z","timestamp":1190678400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Movement Disorders"],"published-print":{"date-parts":[[2007,12,15]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>To investigate the diagnostic value of brain magnetic resonance image (MRI) and <jats:sup>18<\/jats:sup>F\u2010fluorodeoxyglucose positron emission tomography (<jats:sup>18<\/jats:sup>F\u2010FDG PET) in the differentiation of multiple system atrophy (MSA) from Parkinson's disease (PD). Thirty\u2010five patients with MSA (23 MSA\u2010P and 12 MSA\u2010C) and 17 patients with PD were included in this study. Overall correct diagnosis rates between clinical and imaging diagnosis among MSA\u2010P, MSA\u2010C, and PD patients were 80% for visual MRI analysis, 88.5% for visual <jats:sup>18<\/jats:sup>F\u2010FDG PET analysis, and 84.3% for SPM\u2010supported analysis of <jats:sup>18<\/jats:sup>F\u2010FDG PET. The sensitivity of brain MRI, and visual and SPM analysis of <jats:sup>18<\/jats:sup>F\u2010FDG PET in differentiating MSA from PD was 72.7%, 90.9%, and 95.5%, respectively, the specificity was 100% for each imaging analysis, the positive predictive value was 100% for each imaging analysis, and the negative predictive value was 60%, 81.8%, and 90%, respectively. Our results suggest that brain MRI and <jats:sup>18<\/jats:sup>F\u2010FDG PET are diagnostically useful in differentiating MSA (MSA\u2010P and MSA\u2010C) from PD, and indicate that <jats:sup>18<\/jats:sup>F\u2010FDG PET has a tendency toward higher sensitivity compared to brain MRI, but a larger longitudinal study including pathological data will be required to confirm our findings. \u00a9 2007 Movement Disorder Society<\/jats:p>","DOI":"10.1002\/mds.21714","type":"journal-article","created":{"date-parts":[[2007,9,25]],"date-time":"2007-09-25T16:48:32Z","timestamp":1190738912000},"page":"2352-2358","source":"Crossref","is-referenced-by-count":48,"title":["Comparison of brain MRI and <sup>18<\/sup>F\u2010FDG PET in the differential diagnosis of multiple system atrophy from Parkinson's disease"],"prefix":"10.1002","volume":"22","author":[{"given":"Kyum\u2010Yil","family":"Kwon","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Choong 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