{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,9]],"date-time":"2026-04-09T04:45:30Z","timestamp":1775709930508,"version":"3.50.1"},"reference-count":18,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2007,12,20]],"date-time":"2007-12-20T00:00:00Z","timestamp":1198108800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Movement Disorders"],"published-print":{"date-parts":[[2008,3,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    The objective of this study was to compare efficacy, safety, and duration of botulinum toxin type A (BoNT\u2010A) and type B (BoNT\u2010B) in toxin\u2010na\u00efve cervical dystonia (CD) subjects. BoNT\u2010na\u00efve CD subjects were randomized to BoNT\u2010A or BoNT\u2010B and evaluated in a double\u2010blind trial at baseline and every 4\u2010weeks following one treatment. The primary measure was the change in Toronto Western Spasmodic Torticollis Rating Scale (TWSTRS) from baseline to week 4 post\u2010injection. Secondary measures included change in TWSTRS\u2010subscale scores, pain, global impressions, and duration of response and safety assessments. The study was designed as a noninferiority trial of BoNT\u2010B to BoNT\u2010A. 111 subjects were randomized (55 BoNT\u2010A; 56 BoNT\u2010B). Improvement in TWSTRS\u2010total scores 4 weeks after BoNT\u2010B was noninferior to BoNT\u2010A (adjusted means 11.0 (SE 1.2) and 8.8 (SE 1.2), respectively; per\u2010protocol\u2010population (PPP)). The median duration of effect of BoNT\u2010A and BoNT\u2010B was not different (13.1 vs. 13.7 weeks, respectively;\n                    <jats:italic>P<\/jats:italic>\n                    \u2010value = 0.833; PPP). There were no significant differences in the occurrence of injection site pain and dysphagia. Mild dry mouth was more frequent with BoNT\u2010B but there were no differences for moderate\/severe dry mouth. In this study, both BoNT\u2010A and B were shown to be effective and safe for the treatment of toxin\u2010naive CD subjects. \u00a9 2007 Movement Disorder Society\n                  <\/jats:p>","DOI":"10.1002\/mds.21724","type":"journal-article","created":{"date-parts":[[2007,12,20]],"date-time":"2007-12-20T16:51:29Z","timestamp":1198169489000},"page":"510-517","source":"Crossref","is-referenced-by-count":106,"title":["Botulinum toxin type B vs. type A in toxin\u2010na\u00efve patients with cervical dystonia: Randomized, double\u2010blind, noninferiority trial"],"prefix":"10.1002","volume":"23","author":[{"given":"Eric J.","family":"Pappert","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Terry","family":"Germanson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2007,12,20]]},"reference":[{"key":"e_1_2_7_2_2","first-page":"5","volume-title":"Dystonia: etiology, clinical features, and treatment","author":"Brin MF","year":"2004"},{"key":"e_1_2_7_3_2","article-title":"Botulinum toxin type B for cervical dystonia","author":"Costa J","year":"2004","journal-title":"Cochrane Database Syst Rev"},{"key":"e_1_2_7_4_2","article-title":"Botulinum toxin type A for cervical dystonia","author":"Costa J","year":"2005","journal-title":"Cochrane Database Syst Rev"},{"key":"e_1_2_7_5_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1468-1331.2001.00003.x"},{"key":"e_1_2_7_6_2","first-page":"211","volume-title":"Therapy with botulinum toxin","author":"Consky ES","year":"1994"},{"key":"e_1_2_7_7_2","doi-asserted-by":"publisher","DOI":"10.1002\/mds.870120414"},{"key":"e_1_2_7_8_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.49.3.701"},{"key":"e_1_2_7_9_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.53.7.1431"},{"key":"e_1_2_7_10_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.53.7.1439"},{"key":"e_1_2_7_11_2","doi-asserted-by":"publisher","DOI":"10.1212\/01.wnl.0000183055.81056.5c"},{"key":"e_1_2_7_12_2","doi-asserted-by":"publisher","DOI":"10.1002\/mds.870120526"},{"key":"e_1_2_7_13_2","doi-asserted-by":"publisher","DOI":"10.1212\/01.WNL.0000163767.99354.C3"},{"key":"e_1_2_7_14_2","doi-asserted-by":"publisher","DOI":"10.1212\/01.wnl.0000174433.76707.8c"},{"key":"e_1_2_7_15_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.iio.0000167167.10402.74"},{"key":"e_1_2_7_16_2","doi-asserted-by":"publisher","DOI":"10.1212\/01.wnl.0000249308.66959.43"},{"key":"e_1_2_7_17_2","first-page":"A290","article-title":"A 4 year observational study of repeated dosing with botulinum toxin type B in patients with cervical dystonia","volume":"66","author":"Lew MF","year":"2006","journal-title":"Neurology"},{"key":"e_1_2_7_18_2","doi-asserted-by":"publisher","DOI":"10.1002\/mds.20531"},{"key":"e_1_2_7_19_2","first-page":"A252","article-title":"Factors associated with dysphagia after treatment with botulinum toxin serotype A and B","volume":"66","author":"Comella C","year":"2006","journal-title":"Neurology"}],"container-title":["Movement Disorders"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fmds.21724","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/movementdisorders.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/mds.21724","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T08:54:58Z","timestamp":1760950498000},"score":1,"resource":{"primary":{"URL":"https:\/\/movementdisorders.onlinelibrary.wiley.com\/doi\/10.1002\/mds.21724"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,12,20]]},"references-count":18,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2008,3,15]]}},"alternative-id":["10.1002\/mds.21724"],"URL":"https:\/\/doi.org\/10.1002\/mds.21724","archive":["Portico"],"relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.1108442.564498","asserted-by":"object"}]},"ISSN":["0885-3185","1531-8257"],"issn-type":[{"value":"0885-3185","type":"print"},{"value":"1531-8257","type":"electronic"}],"subject":[],"published":{"date-parts":[[2007,12,20]]}}}