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We carried out immunohistochemical studies using antibodies to calbindin (CALB) and calcineurin (CaN) as neurochemical markers for striatal medium spiny neurons. We found that in the caudal and dorsolateral putamen, the area most affected in MSA\u2010P, the medium spiny neurons positive for CALB were severely depleted, while CaN\u2010positive neurons were relatively spared in a mosaic pattern. In the dorsal caudate nucleus, an area less affected in MSA, residual CALB\u2010positive neurons exhibited a compartmentalized distribution that corresponded with the striosomal arrangement visualized by Met\u2010enkephalin immunostaining. Our findings suggest that there is a compartmental difference in the susceptibility of striatal medium spiny neurons to neurodegeneration in MSA\u2010P. \u00a9 2007 Movement Disorder Society<\/jats:p>","DOI":"10.1002\/mds.21732","type":"journal-article","created":{"date-parts":[[2007,9,25]],"date-time":"2007-09-25T16:47:50Z","timestamp":1190738870000},"page":"2365-2370","source":"Crossref","is-referenced-by-count":26,"title":["Compartmental loss of striatal medium spiny neurons in multiple system atrophy of parkinsonian 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