{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T22:59:25Z","timestamp":1777417165061,"version":"3.51.4"},"reference-count":42,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2007,11,12]],"date-time":"2007-11-12T00:00:00Z","timestamp":1194825600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Spanish Health Research Agency","award":["FIS 93\/0773"],"award-info":[{"award-number":["FIS 93\/0773"]}]},{"name":"Spanish Health Research Agency","award":["96\/1993"],"award-info":[{"award-number":["96\/1993"]}]},{"name":"Spanish Office of Science and Technology"},{"name":"National Institutes of Health, Bethesda, MD","award":["NIH R01 NS042859"],"award-info":[{"award-number":["NIH R01 NS042859"]}]},{"name":"National Institutes of Health, Bethesda, MD","award":["R01 NS039422"],"award-info":[{"award-number":["R01 NS039422"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Movement Disorders"],"published-print":{"date-parts":[[2008,1,30]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Parkinson's disease (PD) is inversely associated with smoking cigarettes. Despite long\u2010standing clinical links between PD and essential tremor (ET), there are surprisingly few data on smoking in ET. We studied whether smoking cigarettes is inversely associated with ET. Using a population\u2010based, case\u2013control design, cigarette smoking habits were assessed in 221 prevalent ET cases (75.5 \u00b1 7.1 years old) and 663 matched controls (74.6 \u00b1 7.0 years old). In logistical regression analyses, diagnosis (ET vs. control) was the dependent variable, and cigarette smoking status, the independent variable. Ever smokers were marginally less likely to have ET than were never smokers (22.0% vs. 27.0%, odds ratio [OR] 0.76, 95% confidence interval [CI] 0.55\u20131.04, <jats:italic>P<\/jats:italic> = 0.09). In an analysis that adjusted for confounding factors (drink\u2010years and depressive symptoms), ever smokers were nearly half less likely to have ET than the never smokers (OR 0.58, 95% CI 0.40\u20130.84, <jats:italic>P<\/jats:italic> = 0.004). There was a strong inverse association between pack\u2010years and odds of ET (adjusted OR 0.991, 95% CI 0.984\u20130.997, <jats:italic>P<\/jats:italic> = 0.005, i.e., with every 10 pack\u2010year increase, odds of ET were lowered 10%). Ever smokers in the highest pack\u2010year tertile were one\u2010third as likely to have ET than the never smokers (adjusted OR 0.39, 95% CI 0.22\u20130.69, <jats:italic>P<\/jats:italic> = 0.001). We demonstrated an inverse association between ever smoking and ET. Additional studies are needed to reproduce these findings and assess whether this association is due to a biologically protective effect. \u00a9 2007 Movement Disorder Society<\/jats:p>","DOI":"10.1002\/mds.21810","type":"journal-article","created":{"date-parts":[[2007,11,12]],"date-time":"2007-11-12T21:17:32Z","timestamp":1194902252000},"page":"246-252","source":"Crossref","is-referenced-by-count":22,"title":["Population\u2010based case\u2013control study of cigarette smoking and essential tremor"],"prefix":"10.1002","volume":"23","author":[{"given":"Juli\u00e1n","family":"Benito\u2010Le\u00f3n","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elan D.","family":"Louis","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F\u00e9lix","family":"Bermejo\u2010Pareja","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"Neurological Disorders 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