{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,7]],"date-time":"2026-07-07T17:27:50Z","timestamp":1783445270098,"version":"3.54.6"},"reference-count":19,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2007,12,7]],"date-time":"2007-12-07T00:00:00Z","timestamp":1196985600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Spanish Fondo de Investigaciones Sanitarias","award":["FIS 02\/0648"],"award-info":[{"award-number":["FIS 02\/0648"]}]},{"name":"Spanish Fondo de Investigaciones Sanitarias","award":["FIS 07\/0390"],"award-info":[{"award-number":["FIS 07\/0390"]}]},{"name":"Spanish Fondo de Investigaciones Sanitarias","award":["FIS 05\/0776"],"award-info":[{"award-number":["FIS 05\/0776"]}]},{"name":"Spanish Fondo de Investigaciones Sanitarias","award":["FIS 06\/1298"],"award-info":[{"award-number":["FIS 06\/1298"]}]},{"name":"Spanish Fondo de Investigaciones Sanitarias","award":["FIS 05\/1570"],"award-info":[{"award-number":["FIS 05\/1570"]}]},{"name":"Fundaci\u00f3 La Marat\u00f3 de","award":["TV3 146\/2006"],"award-info":[{"award-number":["TV3 146\/2006"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Movement Disorders"],"published-print":{"date-parts":[[2008,2,15]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Hyperkinetic movements in amyotrophic lateral sclerosis (ALS) are extremely rare. We present clinical, neuropathological, and genetic data for a 53\u2010year\u2010old woman with spinal onset ALS presenting chorea affecting the face, mouth, neck, and hands, and ballism in both arms 31 months after leg weakness onset. Her father and older sister had ALS, but had no movement disorders. As well as the typical neuropathological findings of ALS (marked upper and lower motor neuron loss), post\u2010mortem examination showed prominent neuronal loss and gliosis in the subthalamus, and in the internal globus pallidus, substantia nigra pars compacta, and red nucleus. No abnormalities were found in the caudate, putamen, and thalamus. No defects were found in the <jats:italic>SOD1<\/jats:italic>, <jats:italic>HD<\/jats:italic>, and <jats:italic>DRPLA<\/jats:italic> genes. These data support the idea that choreo\u2010ballism in ALS Plus may be the result of pallido\u2010luyso\u2010rubro\u2010nigral atrophy, despite not being the result of concomitant <jats:italic>DRPLA<\/jats:italic> based on neuropathological and genetic criteria. \u00a9 2007 Movement Disorder Society<\/jats:p>","DOI":"10.1002\/mds.21856","type":"journal-article","created":{"date-parts":[[2007,12,10]],"date-time":"2007-12-10T09:46:38Z","timestamp":1197279998000},"page":"434-438","source":"Crossref","is-referenced-by-count":13,"title":["Chorea\u2010ballism associated with familial amyotrophic lateral sclerosis. A clinical, genetic, and neuropathological study"],"prefix":"10.1002","volume":"23","author":[{"given":"Josep","family":"Gamez","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marc","family":"Corbera\u2010Bellalta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Montserrat","family":"Mila","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rosa","family":"L\u00f3pez\u2010Lisbona","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susana","family":"Boluda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isidre","family":"Ferrer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2007,12,7]]},"reference":[{"key":"e_1_2_7_2_2","volume-title":"Amyotrophic lateral sclerosis","author":"Mitsumoto H","year":"1998"},{"key":"e_1_2_7_3_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM200105313442207"},{"key":"e_1_2_7_4_2","doi-asserted-by":"publisher","DOI":"10.1080\/146608200300079536"},{"key":"e_1_2_7_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jns.2006.03.006"},{"key":"e_1_2_7_6_2","doi-asserted-by":"publisher","DOI":"10.1002\/mds.10254"},{"key":"e_1_2_7_7_2","doi-asserted-by":"publisher","DOI":"10.1002\/mds.10039"},{"key":"e_1_2_7_8_2","doi-asserted-by":"publisher","DOI":"10.1007\/s004010050539"},{"key":"e_1_2_7_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-510X(99)00021-0"},{"key":"e_1_2_7_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/0022-510X(92)90044-L"},{"key":"e_1_2_7_11_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00698300"},{"key":"e_1_2_7_12_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF02870494"},{"key":"e_1_2_7_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/0304-3940(80)90176-7"},{"key":"e_1_2_7_14_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00313987"},{"key":"e_1_2_7_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/0022-510X(89)90158-5"},{"key":"e_1_2_7_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/0022-510X(90)90165-J"},{"key":"e_1_2_7_17_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.57.4.651"},{"key":"e_1_2_7_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1877-3419(09)70103-5"},{"key":"e_1_2_7_19_2","doi-asserted-by":"publisher","DOI":"10.1017\/S0317167100001505"},{"key":"e_1_2_7_20_2","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/119.4.1153"}],"container-title":["Movement Disorders"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fmds.21856","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fmds.21856","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/movementdisorders.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/mds.21856","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T13:35:49Z","timestamp":1760967349000},"score":1,"resource":{"primary":{"URL":"https:\/\/movementdisorders.onlinelibrary.wiley.com\/doi\/10.1002\/mds.21856"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,12,7]]},"references-count":19,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2008,2,15]]}},"alternative-id":["10.1002\/mds.21856"],"URL":"https:\/\/doi.org\/10.1002\/mds.21856","archive":["Portico"],"relation":{},"ISSN":["0885-3185","1531-8257"],"issn-type":[{"value":"0885-3185","type":"print"},{"value":"1531-8257","type":"electronic"}],"subject":[],"published":{"date-parts":[[2007,12,7]]}}}