{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,2]],"date-time":"2026-06-02T10:32:02Z","timestamp":1780396322572,"version":"3.54.1"},"reference-count":28,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2007,12,7]],"date-time":"2007-12-07T00:00:00Z","timestamp":1196985600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Movement Disorders"],"published-print":{"date-parts":[[2008,2,15]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>We aimed to investigate the accuracy of transcranial brain parenchyma sonography (TCS) for differentiation between idiopathic Parkinson's disease (PD) and essential tremor (ET) in comparison to <jats:sup>123<\/jats:sup>I\u2010FP\u2010CIT SPECT (FP\u2010CIT SPECT). Seventy\u2010four patients, in whom PD or ET was suspected on the basis of clinical criteria, were analyzed. The echogenicity of the substantia nigra (SN) and the striatal binding of dopamine transporters (DAT) were evaluated by TCS and FP\u2010CIT SPECT, respectively. Three patients were excluded due to an insufficient transtemporal bone window using TCS. Forty\u2010six and 25 patients were clinically classified as PD and ET. SPECT revealed a reduced DAT binding in 42 of all 71 included patients. Thirty\u2010six of the 42 patients with abnormal FP\u2010CIT SPECT findings had a pathological SN hyperechogenicity, whereas TCS findings in the remaining 6 patients were normal. In 27 of 29 patients with normal SPECT findings the SN echogenicity was regular. Referring to FP\u2010CIT SPECT, the sensitivity and specificity of TCS for detection of PD were 86 and 93%; the positive and negative predictive values were 95 and 82%, respectively. Sensitivity and specificity in detection of clinically diagnosed PD patients were 78 and 92% for TCS and 91 and 100% for FP\u2010CIT SPECT, respectively. In patients with pathological FP\u2010CIT SPECT and pathological TCS, the extent of SN hyperechogenicity did not correlate with the degree of reduction in dopamine transporter binding on the side opposite of the more affected limb. TCS allows a reliable differentiation of PD and ET. The TCS SN hyperechogenicity does not correlate with the extent of dopaminergic neuron degeneration. \u00a9 2007 Movement Disorder Society<\/jats:p>","DOI":"10.1002\/mds.21861","type":"journal-article","created":{"date-parts":[[2007,12,7]],"date-time":"2007-12-07T17:46:37Z","timestamp":1197049597000},"page":"405-410","source":"Crossref","is-referenced-by-count":85,"title":["Brain parenchyma sonography and <sup>123<\/sup>I\u2010FP\u2010CIT SPECT in Parkinson's disease and essential 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