{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T13:00:30Z","timestamp":1788872430276,"version":"build-2803163510"},"reference-count":27,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2008,10,7]],"date-time":"2008-10-07T00:00:00Z","timestamp":1223337600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Novartis Pharma AG, Basel, Switzerland"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Movement Disorders"],"published-print":{"date-parts":[[2009,1,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    We aimed to investigate whether treatment with levodopa\/carbidopa\/entacapone when compared with levodopa\/carbidopa improves quality of life in Parkinson's disease (PD) patients with no or minimal, nondisabling motor fluctuations. This is a multicenter, randomized, double\u2010blind study. One hundred eighty\u2010four patients on 3 to 4 equal doses of 100\/25 to 200\/50 mg levodopa\/carbidopa or levodopa\/benserazide, 0 to 3 hours of nondisabling OFF time over a 48 hour period and no dyskinesia were randomized to levodopa\/carbidopa\/entacapone or levodopa\/carbidopa treatment for 12 weeks. The primary outcome measure was quality of life as assessed by the PDQ\u20108. Secondary outcome measures were the UPDRS parts I\u2013IV, and the Wearing Off Card. Treatment with levodopa\/carbidopa\/entacapone resulted in significantly greater improvements in PDQ\u20108 scores compared to treatment with levodopa\/carbidopa (mean difference 1.4 points,\n                    <jats:italic>P<\/jats:italic>\n                    = 0.021). Statistically significant improvements were seen predominantly in nonmotor domains (depression, personal relationships, communication, stigma, all\n                    <jats:italic>P<\/jats:italic>\n                    &lt; 0.05; dressing\n                    <jats:italic>P =<\/jats:italic>\n                    0.056). Patients who were randomly assigned to levodopa\/carbidopa\/entacapone also showed significantly greater improvement in UPDRS part II scores (\n                    <jats:italic>P<\/jats:italic>\n                    = 0.032) with UPDRS part III scores showing borderline significance. Differences in UPDRS parts I and IV and Wearing Off Card scores were not significant. Treatment with levodopa\/carbidopa\/entacapone results in improved quality of life compared with levodopa\/carbidopa in PD patients with mild or minimal, nondisabling motor fluctuations. \u00a9 2007 Movement Disorder Society\n                  <\/jats:p>","DOI":"10.1002\/mds.21878","type":"journal-article","created":{"date-parts":[[2008,10,7]],"date-time":"2008-10-07T17:13:17Z","timestamp":1223399597000},"page":"25-31","source":"Crossref","is-referenced-by-count":32,"title":["Quality of life in early Parkinson's disease treated with levodopa\/carbidopa\/entacapone"],"prefix":"10.1002","volume":"24","author":[{"given":"Victor S.C.","family":"Fung","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lilie","family":"Herawati","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Wan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"Movement Disorder Society of Australia Clinical Research and Trials Group","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"on behalf of the QUEST\u2010AP Study Group","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2009,1,23]]},"reference":[{"key":"e_1_2_13_2_2","doi-asserted-by":"publisher","DOI":"10.1002\/mds.20464"},{"key":"e_1_2_13_3_2","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.2004.035980"},{"key":"e_1_2_13_4_2","doi-asserted-by":"publisher","DOI":"10.1002\/ana.20789"},{"key":"e_1_2_13_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(05)70098-3"},{"key":"e_1_2_13_6_2","doi-asserted-by":"publisher","DOI":"10.1002\/mds.20461"},{"key":"e_1_2_13_7_2","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.61.10.1563"},{"key":"e_1_2_13_8_2","doi-asserted-by":"publisher","DOI":"10.1002\/mds.10010"},{"key":"e_1_2_13_9_2","doi-asserted-by":"publisher","DOI":"10.1002\/1531-8257(200009)15:5<826::AID-MDS1010>3.0.CO;2-E"},{"key":"e_1_2_13_10_2","doi-asserted-by":"publisher","DOI":"10.1002\/mds.20383"},{"key":"e_1_2_13_11_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.62.1_suppl_1.S72"},{"key":"e_1_2_13_12_2","doi-asserted-by":"publisher","DOI":"10.1007\/PL00007730"},{"key":"e_1_2_13_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.parkreldis.2006.06.006"},{"key":"e_1_2_13_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.parkreldis.2004.05.007"},{"key":"e_1_2_13_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jns.2007.01.072"},{"key":"e_1_2_13_16_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0404.2007.00818.x"},{"key":"e_1_2_13_17_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00702-004-0149-4"},{"key":"e_1_2_13_18_2","doi-asserted-by":"publisher","DOI":"10.1002\/mds.21567"},{"key":"e_1_2_13_19_2","doi-asserted-by":"publisher","DOI":"10.1002\/mds.21099"},{"key":"e_1_2_13_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-510X(99)00198-7"},{"key":"e_1_2_13_21_2","first-page":"283","article-title":"The impact of treatment with levodopa on Parkinson's disease","volume":"49","author":"Shaw KM","year":"1980","journal-title":"Q J Med"},{"key":"e_1_2_13_22_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00415-006-0067-5"},{"key":"e_1_2_13_23_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1520-6394(2000)11:2<58::AID-DA2>3.0.CO;2-H"},{"key":"e_1_2_13_24_2","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.161.3.564"},{"key":"e_1_2_13_25_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jns.2006.05.024"},{"key":"e_1_2_13_26_2","doi-asserted-by":"publisher","DOI":"10.1097\/00004714-199908000-00008"},{"key":"e_1_2_13_27_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.mp.4001808"},{"key":"e_1_2_13_28_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00702-003-0092-9"}],"container-title":["Movement 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