{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,23]],"date-time":"2026-06-23T23:55:06Z","timestamp":1782258906729,"version":"3.54.5"},"reference-count":15,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2008,2,8]],"date-time":"2008-02-08T00:00:00Z","timestamp":1202428800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Movement Disorders"],"published-print":{"date-parts":[[2008,4,15]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Myoclonus\u2010dystonia (M\u2010D) is an autosomal dominant movement disorder caused by mutations in the \u03b5\u2010sarcoglycan gene (<jats:italic>DYT11<\/jats:italic>). We explore pathophysiological characteristics of M\u2010D with the hypothesis that they may be different from those of sporadic or genetic dystonia. We compared five carriers of the <jats:italic>DYT11<\/jats:italic> gene mutation and 10 healthy controls. Using transcranial magnetic stimulation, we measured parameters assessing cortical membrane excitability (active motor threshold, aMT) and synaptic activity (short interval, sICI) and afferent (AI) intracortical inhibitions and their interaction. aMT was significantly higher in the <jats:italic>DYT11<\/jats:italic> gene carriers than in normal subjects. The others parameters (sICI, AI and their interaction) were not different between the two groups. In <jats:italic>DYT11<\/jats:italic> gene carriers cortical membrane excitability was impaired while parameters assessing cortical synaptic activity were normal. Opposite results have been obtained in focal sporadic and generalized <jats:italic>DYT1<\/jats:italic> dystonias. \u00a9 2008 Movement Disorder Society<\/jats:p>","DOI":"10.1002\/mds.21954","type":"journal-article","created":{"date-parts":[[2008,2,8]],"date-time":"2008-02-08T13:46:23Z","timestamp":1202478383000},"page":"761-764","source":"Crossref","is-referenced-by-count":23,"title":["Cortical excitability in DYT\u201011 positive myoclonus dystonia"],"prefix":"10.1002","volume":"23","author":[{"family":"Sabine Meunier","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"family":"George Lourenco","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emmanuel","family":"Roze","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emmanuelle","family":"Apartis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean\u2010Marc","family":"Trocello","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"family":"Marie Vidailhet","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2008,2,8]]},"reference":[{"key":"e_1_2_5_2_2","doi-asserted-by":"publisher","DOI":"10.1002\/mds.21160"},{"key":"e_1_2_5_3_2","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awg209"},{"key":"e_1_2_5_4_2","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.59.5.493"},{"key":"e_1_2_5_5_2","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awg219"},{"key":"e_1_2_5_6_2","doi-asserted-by":"publisher","DOI":"10.1212\/01.wnl.0000257816.92101.54"},{"key":"e_1_2_5_7_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-7793.2001.00891.x"},{"key":"e_1_2_5_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.eplepsyres.2003.08.006"},{"key":"e_1_2_5_9_2","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410400306"},{"key":"e_1_2_5_10_2","doi-asserted-by":"publisher","DOI":"10.1002\/mds.20160"},{"key":"e_1_2_5_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neucli.2006.12.008"},{"key":"e_1_2_5_12_2","doi-asserted-by":"publisher","DOI":"10.1002\/mds.20821"},{"key":"e_1_2_5_13_2","doi-asserted-by":"publisher","DOI":"10.1212\/01.WNL.0000046528.24693.5B"},{"key":"e_1_2_5_14_2","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awh402"},{"key":"e_1_2_5_15_2","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddl472"},{"key":"e_1_2_5_16_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajpcell.2001.281.2.C690"}],"container-title":["Movement Disorders"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fmds.21954","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fmds.21954","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/mds.21954","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/mds.21954","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/movementdisorders.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/mds.21954","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T10:45:01Z","timestamp":1760957101000},"score":1,"resource":{"primary":{"URL":"https:\/\/movementdisorders.onlinelibrary.wiley.com\/doi\/10.1002\/mds.21954"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,2,8]]},"references-count":15,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2008,4,15]]}},"alternative-id":["10.1002\/mds.21954"],"URL":"https:\/\/doi.org\/10.1002\/mds.21954","archive":["Portico"],"relation":{},"ISSN":["0885-3185","1531-8257"],"issn-type":[{"value":"0885-3185","type":"print"},{"value":"1531-8257","type":"electronic"}],"subject":[],"published":{"date-parts":[[2008,2,8]]}}}