{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,31]],"date-time":"2026-07-31T15:39:15Z","timestamp":1785512355747,"version":"3.56.0"},"reference-count":35,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2008,3,31]],"date-time":"2008-03-31T00:00:00Z","timestamp":1206921600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"NWO VIDI","award":["016.076.352"],"award-info":[{"award-number":["016.076.352"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Movement Disorders"],"published-print":{"date-parts":[[2008,5,15]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Falls are common in patients with Huntington's disease, but the incidence, falling circumstances and contributing factors have never been examined. We recorded falls in 45 early to midstage Huntington's disease patients, both retrospectively (12 months) and prospectively (3 months). Fall rates were related to relevant baseline measures, including the Unified Huntington's Disease Rating Scale (UHDRS) and quantitative measures of balance (using angular velocity sensors) and gait (using a pressure\u2010sensitive walkway). Balance and gait measures were compared between patients and 27 healthy age\u2010matched controls. Twenty\u2010seven patients (60%) reported two or more falls in the previous year and were classified as fallers. During prospective follow\u2010up 40% reported at least one fall. A high proportion of falls (72.5%) caused minor injuries. Compared to nonfallers, fallers showed significantly higher scores for chorea, bradykinesia and aggression, as well as lower cognitive scores. Compared to controls, Huntington patients had a decreased gait velocity (1.15 m\/s versus 1.45 m\/s, <jats:italic>P<\/jats:italic> &lt; 0.001) and a decreased stride length (1.29 m versus 1.52 m, <jats:italic>P<\/jats:italic> &lt; 0.001). These abnormalities were all significantly greater in fallers compared to nonfallers. In addition, fallers had an increased stride length variability and a significantly greater trunk sway in medio\u2010lateral direction compared to nonfallers. We conclude that falls are common in Huntington's disease. Contributing factors include a combination of \u201cmotor\u201d deficits (mainly gait bradykinesia, stride variability and chorea, leading to excessive trunk sway), as well as cognitive decline and perhaps behavioral changes. These factors should be considered as future targets for therapies that aim to reduce falls in Huntington's disease. \u00a9 2008 Movement Disorder Society<\/jats:p>","DOI":"10.1002\/mds.22003","type":"journal-article","created":{"date-parts":[[2008,3,31]],"date-time":"2008-03-31T19:16:28Z","timestamp":1206990988000},"page":"970-976","source":"Crossref","is-referenced-by-count":144,"title":["Falls and gait disturbances in Huntington's disease"],"prefix":"10.1002","volume":"23","author":[{"given":"Yvette A.M.","family":"Grimbergen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mirjam J.","family":"Knol","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bastiaan R.","family":"Bloem","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Berry 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