{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T13:43:48Z","timestamp":1790775828414,"version":"4.1.0"},"reference-count":31,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2008,4,15]],"date-time":"2008-04-15T00:00:00Z","timestamp":1208217600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Movement Disorders"],"published-print":{"date-parts":[[2008,6,15]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>To elucidate characteristic changes of brain acetylcholinesterase (AChE) in cerebellar degenerative disorders. Eight patients with the cerebellar variant of multiple system atrophy (MSA\u2010C), 7 patients with spinocerebellar ataxia type\u20103 (SCA\u20103), 3 patients with SCA\u20106, and 13 healthy age\u2010matched volunteers participated in this study. Brain AChE activity was measured by [<jats:sup>11<\/jats:sup>C] <jats:italic>N<\/jats:italic>\u2010methylpiperidin\u20104\u2010yl propionate PET in all subjects. Brain AChE activities were significantly decreased in the thalamus (\u221227%) and the posterior lobe of cerebellar cortex (\u221236%) in patients with MSA\u2010C and in the thalamus (\u221223%) in patients with SCA\u20103 compared with healthy controls (<jats:italic>P<\/jats:italic> &lt; 0.01). Thalamic AChE activities of SCA\u20103 patients were negatively correlated with the unified Parkinson's disease rating scale motor subscore (<jats:italic>P<\/jats:italic> &lt; 0.001). AChE activities were not significantly altered in the cerebral cortex in any disease group. Reduction of AChE activities in the thalamus and cerebellum in MSA and in the thalamus in SCA\u20103 suggest that cholinergic modulating drugs may have a role in the treatment of ataxia and other symptoms in these disorders. \u00a9 2008 Movement Disorder Society<\/jats:p>","DOI":"10.1002\/mds.22056","type":"journal-article","created":{"date-parts":[[2008,4,15]],"date-time":"2008-04-15T18:46:37Z","timestamp":1208285197000},"page":"1154-1160","source":"Crossref","is-referenced-by-count":33,"title":["PET study of brain acetylcholinesterase in cerebellar degenerative 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