{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T10:25:39Z","timestamp":1791109539537,"version":"4.1.0"},"reference-count":19,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2008,4,28]],"date-time":"2008-04-28T00:00:00Z","timestamp":1209340800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Movement Disorders"],"published-print":{"date-parts":[[2008,6,15]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Thalamic stimulation and thalamotomy for treatment of tremor due to Parkinson's disease, essential tremor, and multiple sclerosis were compared in a randomized trial. The symptomatic and functional outcome was studied after 5 years of follow\u2010up. Sixty\u2010eight patients were treated (45 Parkinson's disease, 13 essential tremor, 10 multiple sclerosis) by thalamotomy (n = 34) or thalamic stimulation (n = 34). After 5 years, 48 patients were available for follow\u2010up. The primary outcome measure was change in functional status measured by the Frenchay Activities Index (FAI), scores ranging from 0 to 60. Secondary outcome measures were tremor severity, frequency of complications, and patients' assessment of the outcome. The mean difference in FAI scores between thalamic stimulation and thalamotomy was 4.4 (95% CI: 1.1\u20137.7) after 6 months, 3.3 (95% CI: \u22120.03\u20136.6) after 2 years and 4.0 (95% CI: 0.3\u20137.7) after 5 years in favor of stimulation. Tremor suppression was equally effective after both procedures, and stable in Parkinson patients. In ET and multiple sclerosis, a diminished effect of stimulation was observed in half of the patients. There were six stimulation equipment\u2010related complications, but neurological side effects of surgery were higher after thalamotomy. Subjective outcome\u2010assessment by the patients was more favorable in the stimulation group. \u00a9 2008 Movement Disorder Society.<\/jats:p>","DOI":"10.1002\/mds.22059","type":"journal-article","created":{"date-parts":[[2008,4,28]],"date-time":"2008-04-28T17:46:45Z","timestamp":1209404805000},"page":"1146-1153","source":"Crossref","is-referenced-by-count":163,"title":["Long\u2010term follow\u2010up of thalamic stimulation versus thalamotomy for tremor suppression"],"prefix":"10.1002","volume":"23","author":[{"given":"P. Richard","family":"Schuurman","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D. 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