{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T06:28:30Z","timestamp":1789972110613,"version":"4.0.1"},"reference-count":71,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2008,4,28]],"date-time":"2008-04-28T00:00:00Z","timestamp":1209340800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Movement Disorders"],"published-print":{"date-parts":[[2008,6,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Idiopathic Parkinson disease (PD) is traditionally considered a movement disorder with hallmark lesions located in the substantia nigra pars compacta (SNpc). However, recent histopathological studies of some PD cases suggest the possibility of a multisystem disorder which progresses in a predictable sequence as described in Braak's staging criteria. The disease process starts in the dorsal motor nucleus of the vagus (dmX) and anterior olfactory nucleus and bulb, and from there, spreads through the brainstem nuclei to ultimately reach the SNpc, which then presents as symptomatic PD. In this article, we would like to revisit the olfactory pathogenesis of PD based on Braak's staging system and review anatomical pathways supporting such a possibility. We also suggest some biomarkers for early stages of PD. Additionally, we present and discuss the possibility that a prion\u2010like process underlies the neurodegenerative changes in PD. \u00a9 2008 Movement Disorder Society<\/jats:p>","DOI":"10.1002\/mds.22066","type":"journal-article","created":{"date-parts":[[2008,4,28]],"date-time":"2008-04-28T18:17:38Z","timestamp":1209406658000},"page":"1076-1084","source":"Crossref","is-referenced-by-count":62,"title":["Olfactory pathogenesis of idiopathic Parkinson disease 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