{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T00:46:15Z","timestamp":1761007575831,"version":"build-2065373602"},"reference-count":15,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2008,8,16]],"date-time":"2008-08-16T00:00:00Z","timestamp":1218844800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Movement Disorders"],"published-print":{"date-parts":[[2008,9,15]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Blood concentrations of harmane, a tremor\u2010producing neurotoxin, are elevated in essential tremor (ET). Harmane is also a comutagen. Using a case\u2010control design, we compared the prevalence of cancer in ET cases vs. controls, and determined whether blood harmane concentrations are elevated among ET cases with cancer. 66\/267 (24.7%) ET cases vs. 55\/331 (16.6%) controls had cancer (adjusted OR 1.52, 95% CI 1.01\u20132.30, <jats:italic>P<\/jats:italic> = 0.04). Among specific cancer types, colon cancer was more prevalent in ET cases than controls (2.6% vs. 0.6%, <jats:italic>P<\/jats:italic> = 0.04). Log blood harmane concentration was higher in ET cases vs. controls (<jats:italic>P<\/jats:italic> = 0.02) and in participants with vs. without cancer (<jats:italic>P<\/jats:italic> = 0.02). Log blood harmane concentration was highest in ET cases with cancer when compared with other groups (<jats:italic>P<\/jats:italic> = 0.009). These links between cancer and ET and between high blood harmane and cancer in ET deserve further study. \u00a9 2008 Movement Disorder Society<\/jats:p>","DOI":"10.1002\/mds.22084","type":"journal-article","created":{"date-parts":[[2008,8,16]],"date-time":"2008-08-16T14:33:21Z","timestamp":1218897201000},"page":"1747-1751","source":"Crossref","is-referenced-by-count":3,"title":["Cancer and blood concentrations of the comutagen harmane in essential tremor"],"prefix":"10.1002","volume":"23","author":[{"given":"Elan D.","family":"Louis","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kathryn M.","family":"Pellegrino","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pam","family":"Factor\u2010Litvak","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eileen","family":"Rios","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wendy","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Claire","family":"Henchcliffe","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wei","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2008,8,16]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/0165-1110(95)90008-X"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuropharm.2005.08.022"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1002\/mds.20331"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1212\/01.wnl.0000172352.88359.2d"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.pcan.4500941"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1124\/dmd.106.013532"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0304-3835(99)00143-3"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/0278-6915(94)90073-6"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.1158\/1055-9965.EPI-07-0377"},{"key":"e_1_2_6_11_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1532-5415.1968.tb02103.x"},{"key":"e_1_2_6_12_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.50.5.1351"},{"key":"e_1_2_6_13_2","doi-asserted-by":"publisher","DOI":"10.1006\/abio.1999.4456"},{"key":"e_1_2_6_14_2","doi-asserted-by":"publisher","DOI":"10.1017\/S0317167100044541"},{"key":"e_1_2_6_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.pnpbp.2007.08.043"},{"key":"e_1_2_6_16_2","unstructured":"Cancer incidence and mortality by age group and region 2000\u20132004 New York State. Available at:www.health.state.ny\/us\/statistics\/cancer\/registry."}],"container-title":["Movement Disorders"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fmds.22084","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/movementdisorders.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/mds.22084","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T14:16:53Z","timestamp":1760969813000},"score":1,"resource":{"primary":{"URL":"https:\/\/movementdisorders.onlinelibrary.wiley.com\/doi\/10.1002\/mds.22084"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,8,16]]},"references-count":15,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2008,9,15]]}},"alternative-id":["10.1002\/mds.22084"],"URL":"https:\/\/doi.org\/10.1002\/mds.22084","archive":["Portico"],"relation":{},"ISSN":["0885-3185","1531-8257"],"issn-type":[{"type":"print","value":"0885-3185"},{"type":"electronic","value":"1531-8257"}],"subject":[],"published":{"date-parts":[[2008,8,16]]}}}