{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T09:21:33Z","timestamp":1791105693891,"version":"4.1.0"},"reference-count":8,"publisher":"Wiley","issue":"13","license":[{"start":{"date-parts":[[2008,8,29]],"date-time":"2008-08-29T00:00:00Z","timestamp":1219968000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Movement Disorders"],"published-print":{"date-parts":[[2008,10,15]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The anti\u2010parkinsonian and levodopa\u2010sparing potential of the nociceptin\/orphanin FQ receptor (NOP) antagonist J\u2010113397 has been demonstrated in rodent models of Parkinson's disease. Here, we describe the levodopa\u2010sparing potential of J\u2010113397 in MPTP\u2010lesioned marmosets. Coadministration of J\u2010113397 (30 mg\/kg) with a sub\u2010therapeutic dose of levodopa (12.5 mg\/kg) produced an anti\u2010parkinsonian action equivalent to that of a therapeutic dose of levodopa. However, these effects were accompanied by an equivalent level of dyskinesia. The actions of NOP antagonists seen in rodents translate to nonhuman primates. However, the present study raises the possibility that these levodopa\u2010sparing benefits may be offset by a propensity to exacerbate dyskinesia. \u00a9 2008 Movement Disorder Society<\/jats:p>","DOI":"10.1002\/mds.22086","type":"journal-article","created":{"date-parts":[[2008,8,29]],"date-time":"2008-08-29T11:47:40Z","timestamp":1220010460000},"page":"1922-1925","source":"Crossref","is-referenced-by-count":36,"title":["The nociceptin\/orphanin FQ (NOP) receptor antagonist J\u2010113397 enhances the effects of levodopa in the MPTP\u2010lesioned nonhuman primate model of Parkinson's disease"],"prefix":"10.1002","volume":"23","author":[{"given":"Naomi P.","family":"Visanji","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rob M.A.","family":"de Bie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tom H.","family":"Johnston","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew C.","family":"McCreary","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonathan M.","family":"Brotchie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susan H.","family":"Fox","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2008,10,27]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1002\/mds.20612"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1002\/mds.21475"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrd2087"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.4346-06.2007"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.2546-05.2005"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.0987-04.2004"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1002\/mds.21073"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1002\/mds.20828"}],"container-title":["Movement Disorders"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fmds.22086","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/movementdisorders.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/mds.22086","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T08:51:51Z","timestamp":1760950311000},"score":1,"resource":{"primary":{"URL":"https:\/\/movementdisorders.onlinelibrary.wiley.com\/doi\/10.1002\/mds.22086"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,10,15]]},"references-count":8,"journal-issue":{"issue":"13","published-print":{"date-parts":[[2008,10,15]]}},"alternative-id":["10.1002\/mds.22086"],"URL":"https:\/\/doi.org\/10.1002\/mds.22086","archive":["Portico"],"relation":{},"ISSN":["0885-3185","1531-8257"],"issn-type":[{"value":"0885-3185","type":"print"},{"value":"1531-8257","type":"electronic"}],"subject":[],"published":{"date-parts":[[2008,10,15]]}}}