{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T00:09:58Z","timestamp":1790122198539,"version":"4.0.1"},"reference-count":25,"publisher":"Wiley","issue":"13","license":[{"start":{"date-parts":[[2008,9,10]],"date-time":"2008-09-10T00:00:00Z","timestamp":1221004800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Movement Disorders"],"published-print":{"date-parts":[[2008,10,15]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Longitudinal studies of neurocognitive function in prediagnosis Huntington disease (pre\u2010HD) have been few, and duration of follow\u2010up has been brief. In this study, 155 individuals at\u2010risk for HD completed a battery of cognitive and motor tasks at two study visits \u223c10 years apart. Participants were classified as: (1) at\u2010risk, without the CAG expansion (healthy controls, NC; n = 112), or (2) CAG expanded (CAG+; n = 43). To examine the rate of decline at different stages of the pre\u2010HD period, participants in the CAG+ group were further characterized as converters (i.e., individuals who developed manifest HD over the course of the study; n = 21) or nonconverters (n = 22), and their performances were compared. The CAG+ group exhibited faster rates of neurocognitive decline over the course of the study, relative to the NC group. In addition, more rapid decline was associated with closer proximity to estimated age of disease onset in the CAG+ group. Faster rates of motor and psychomotor decline were observed in the CAG+ converter group, relative to the nonconverters. These findings suggest that neurocognitive decline in pre\u2010HD, particularly in motor and psychomotor domains, begins insidiously and accelerates as individuals approach disease onset. \u00a9 2008 Movement Disorder Society<\/jats:p>","DOI":"10.1002\/mds.22097","type":"journal-article","created":{"date-parts":[[2008,9,10]],"date-time":"2008-09-10T13:58:45Z","timestamp":1221055125000},"page":"1830-1836","source":"Crossref","is-referenced-by-count":43,"title":["Ten\u2010year rate of longitudinal change in neurocognitive and motor function in prediagnosis Huntington disease"],"prefix":"10.1002","volume":"23","author":[{"given":"Andrea C.","family":"Solomon","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julie 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