{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T08:21:35Z","timestamp":1782980495754,"version":"3.54.5"},"reference-count":22,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2008,6,10]],"date-time":"2008-06-10T00:00:00Z","timestamp":1213056000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Movement Disorders"],"published-print":{"date-parts":[[2008,8,15]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The aim of this study was to determine the effectiveness of brain proton magnetic resonance spectroscopy (<jats:sup>1<\/jats:sup>H\u2010MRS) for monitoring therapy in Wilson's disease (WD) patients. Voxels were located in the globus pallidus (right, left). We followed 17 newly diagnosed WD cases for 1\u2010year period. During this observation period, 6 neurological and 9 hepatic patients improved, while 2 neurological patients deteriorated. The pretreatment <jats:sup>1<\/jats:sup>H\u2010MRS analysis showed a statistically significant lower level of mI\/Cr, NAA\/Cr, and higher Lip\/Cr in all WD patients with improvement compared with controls. In patients with hepatic signs, a statistically significant increase of mI\/Cr and Glx\/Cr was observed in the second (1 year posttreatment) <jats:sup>1<\/jats:sup>H\u2010MRS. In patients with neurological improvement after treatment in the follow\u2010up <jats:sup>1<\/jats:sup>H\u2010MRS, a statistically significant increase of NAA\/Cr was noted. During neurological deterioration, a decrease of Glx\/Cr and NAA\/Cr was seen, in contrast to another neurologically impaired patient with liver failure exacerbation, where a decrease of mI\/Cr and increase of Glx\/Cr was observed. The alternations of NAA\/Cr ratio in neurologically impaired patients and mI\/Cr and Glx\/Cr in patients with liver failure could be a sensitive marker of the clinical recovery and deterioration in those WD patients. <jats:sup>1<\/jats:sup>H\u2010MRS is a technique that can be used for accurate monitoring of treatment efficacy in WD patients. \u00a9 2008 Movement Disorder Society<\/jats:p>","DOI":"10.1002\/mds.22163","type":"journal-article","created":{"date-parts":[[2008,6,10]],"date-time":"2008-06-10T18:17:35Z","timestamp":1213121855000},"page":"1560-1566","source":"Crossref","is-referenced-by-count":33,"title":["MR spectroscopy in monitoring the treatment of Wilson's disease patients"],"prefix":"10.1002","volume":"23","author":[{"given":"Beata","family":"Tarnacka","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wojciech","family":"Szeszkowski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marek","family":"Golebiowski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Czlonkowska","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2008,6,10]]},"reference":[{"key":"e_1_2_6_2_2","first-page":"14","volume-title":"Wilson's disease","author":"Hoogenraad T","year":"1997"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00415-005-0720-4"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00588068"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00593969"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.56.8.919"},{"key":"e_1_2_6_7_2","doi-asserted-by":"crossref","first-page":"1","DOI":"10.4324\/9780429177200","volume-title":"Magnetic resonance spectroscopy diagnosis of neurological diseases","author":"Danielsen E","year":"1999"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1148\/radiology.209.1.9769815"},{"key":"e_1_2_6_9_2","first-page":"175","article-title":"Observation on copper metabolism in Wilson's disease","volume":"56","author":"Czlonkowska A","year":"1973","journal-title":"Acta Univ Carol Med"},{"key":"e_1_2_6_10_2","unstructured":"MarcusC SargentoniJ BryantD Taylor\u2010RobinsonS.1H MRS in patients with chronic hepatic encephalopathy: regional variations. 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