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Impaired mitochondrial function has long been implicated in the pathogenesis of Parkinson's disease (PD), and therefore, we evaluated the relationship of the <jats:italic>HD<\/jats:italic> CAG repeat size to PD onset age in a large sample of familial PD cases. PD affected siblings (n = 495), with known onset ages from 248 families, were genotyped for the <jats:italic>HD<\/jats:italic> CAG repeat. Genotyping failed in 11 cases leaving 484 for analysis, including 35 <jats:italic>LRRK2<\/jats:italic> carriers. All cases had <jats:italic>HD<\/jats:italic> CAG repeats (range, 15\u201334) below the clinical range for HD, although 5.2% of the sample (n = 25) had repeats in the intermediate range (the intermediate range lower limit = 27; upper limit = 35 repeats), suggesting that the prevalence of intermediate allele carriers in the general population is significant. No relation between the <jats:italic>HD<\/jats:italic> CAG repeat size and the age at onset for PD was found in this sample of familial PD. \u00a9 2008 Movement Disorder Society<\/jats:p>","DOI":"10.1002\/mds.22186","type":"journal-article","created":{"date-parts":[[2008,7,22]],"date-time":"2008-07-22T16:27:19Z","timestamp":1216744039000},"page":"1596-1601","source":"Crossref","is-referenced-by-count":6,"title":["Huntington CAG repeat size does not modify onset age in familial Parkinson's disease: The <i>Gene<\/i>PD study"],"prefix":"10.1002","volume":"23","author":[{"given":"Christopher F.","family":"McNicoll","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jeanne C.","family":"Latourelle","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marcy E.","family":"MacDonald","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mark F.","family":"Lew","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Oksana","family":"Suchowersky","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christine","family":"Klein","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lawrence I.","family":"Golbe","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Margery H.","family":"Mark","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John H.","family":"Growdon","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G. 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