{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,22]],"date-time":"2026-01-22T19:04:28Z","timestamp":1769108668903,"version":"3.49.0"},"reference-count":17,"publisher":"Wiley","issue":"15","license":[{"start":{"date-parts":[[2008,9,24]],"date-time":"2008-09-24T00:00:00Z","timestamp":1222214400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Movement Disorders"],"published-print":{"date-parts":[[2008,11,15]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Huntington's disease\u2010like 2 (HDL2) is a neurodegenerative disorder found in people of African ancestry with clinical, radiological, and neuropathological manifestations similar to Huntington's disease (HD). HDL2 is caused by a pathological expansion of CAG\/CTG triplets in exon 2A of the <jats:italic>JPH3<\/jats:italic> gene. We describe four cases of HDL2 from four unrelated families, and discuss their clinical findings. HDL2 should be considered in every patient with an HD\u2010like phenotype who tests negative for the HD mutation, even if African ancestry is not immediately apparent. \u00a9 2008 Movement Disorder Society<\/jats:p>","DOI":"10.1002\/mds.22223","type":"journal-article","created":{"date-parts":[[2008,9,24]],"date-time":"2008-09-24T15:57:14Z","timestamp":1222271834000},"page":"2244-2247","source":"Crossref","is-referenced-by-count":25,"title":["Huntington's disease\u2010like 2 in Brazil\u2014Report of 4 patients"],"prefix":"10.1002","volume":"23","author":[{"given":"Guilherme G. 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National Census 2000. Available at:http:\/\/www.ibge.gov.br\/home\/presidencia\/noticias\/20122002censo.shtm."},{"key":"e_1_2_5_18_2","unstructured":"KrauseA TemlettJ Van der MeydenK RossCA CallahanC MargolisRL.CAG\/CTG repeat expansions at the HDL2 locus are a common cause of Huntington disease in Black South Africans. Presented at the Annual Meeting of The American Society of Human Genetics 15 October 2002 Baltimore Maryland. (Abstract program number: 2098)"}],"container-title":["Movement Disorders"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fmds.22223","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/movementdisorders.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/mds.22223","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T14:36:14Z","timestamp":1760970974000},"score":1,"resource":{"primary":{"URL":"https:\/\/movementdisorders.onlinelibrary.wiley.com\/doi\/10.1002\/mds.22223"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,9,24]]},"references-count":17,"journal-issue":{"issue":"15","published-print":{"date-parts":[[2008,11,15]]}},"alternative-id":["10.1002\/mds.22223"],"URL":"https:\/\/doi.org\/10.1002\/mds.22223","archive":["Portico"],"relation":{},"ISSN":["0885-3185","1531-8257"],"issn-type":[{"value":"0885-3185","type":"print"},{"value":"1531-8257","type":"electronic"}],"subject":[],"published":{"date-parts":[[2008,9,24]]}}}